Evaluating two series of layered double hydroxides in the fight against microorganisms

IF 5.3 2区 地球科学 Q2 CHEMISTRY, PHYSICAL
Anna Donnadio , Tamara Posati , Livia Ottaviano , Severino Zara , Francesco Fancello , Salvatore Marceddu , Andrea Migliori , Morena Nocchetti
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引用次数: 0

Abstract

The increasing prevalence of antimicrobial resistance has created a need for the development of innovative antimicrobial strategies beyond traditional antibiotics. Layered double hydroxides, with their tunable chemical composition and controlled ion release capabilities, have emerged as promising candidates for facing multidrug-resistant pathogens. In this study, layered double hydroxides were synthesized using co-precipitation and double microemulsion methods to produce nanoparticles with distinct particle sizes (diameter and thickness) and intercalated anions. Their antimicrobial activity was evaluated against different bacterial and fungal strains, including Staphylococcus aureus and Candida albicans. The results revealed that layered double hydroxides with smaller particle sizes and intercalated bromide anions demonstrated superior antibacterial efficacy, attributable to enhanced ion release and increased interaction with microbial membranes. Notably, layered double hydroxides prepared by double microemulsion and containing Mg(II), Cu(II), Al(III) and bromide anions exhibited the highest antimicrobial activity, highlighting the impact of particle dimensions and intercalated anion properties on performance. This work highlights the potential of layered double hydroxides based materials as versatile antimicrobial agents, offering a sustainable solution to address the challenges of antimicrobial resistance in clinical and environmental applications.

Abstract Image

评价两个系列的层状双氢氧化物在对抗微生物中的作用
抗菌素耐药性日益普遍,因此需要开发超越传统抗生素的创新抗菌素战略。层状双氢氧化物具有可调节的化学成分和可控制的离子释放能力,已成为面对多药耐药病原体的有希望的候选者。在本研究中,采用共沉淀法和双微乳液法合成了层状双氢氧化物,制备了具有不同粒径(直径和厚度)和嵌入阴离子的纳米颗粒。对不同的细菌和真菌菌株,包括金黄色葡萄球菌和白色念珠菌进行了抑菌活性评估。结果表明,粒径较小的层状双氢氧化物和插入溴化物阴离子表现出优异的抗菌效果,这是由于离子释放增强和与微生物膜的相互作用增加。值得注意的是,由双微乳液制备的含有Mg(II)、Cu(II)、Al(III)和溴化物阴离子的层状双氢氧化物的抗菌活性最高,这表明颗粒尺寸和插层阴离子性质对性能的影响。这项工作强调了层状双氢氧化物基材料作为多功能抗菌剂的潜力,为解决临床和环境应用中抗菌素耐药性的挑战提供了可持续的解决方案。
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来源期刊
Applied Clay Science
Applied Clay Science 地学-矿物学
CiteScore
10.30
自引率
10.70%
发文量
289
审稿时长
39 days
期刊介绍: Applied Clay Science aims to be an international journal attracting high quality scientific papers on clays and clay minerals, including research papers, reviews, and technical notes. The journal covers typical subjects of Fundamental and Applied Clay Science such as: • Synthesis and purification • Structural, crystallographic and mineralogical properties of clays and clay minerals • Thermal properties of clays and clay minerals • Physico-chemical properties including i) surface and interface properties; ii) thermodynamic properties; iii) mechanical properties • Interaction with water, with polar and apolar molecules • Colloidal properties and rheology • Adsorption, Intercalation, Ionic exchange • Genesis and deposits of clay minerals • Geology and geochemistry of clays • Modification of clays and clay minerals properties by thermal and physical treatments • Modification by chemical treatments with organic and inorganic molecules(organoclays, pillared clays) • Modification by biological microorganisms. etc...
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