Maternal exposure to polychlorinated biphenyls in indoor air and asthma, allergic rhinitis, atopic eczema, and respiratory tract infections in childhood

IF 4.5 2区 医学 Q1 INFECTIOUS DISEASES
Laura Deen , Karin Sørig Hougaard , Harald William Meyer , Camilla Sandal Sejbæk , Kajsa Ugelvig Petersen , Marie Frederiksen , Jens Peter Bonde , Marie Standl , Claudia Flexeder , Sandra Søgaard Tøttenborg
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Abstract

Polychlorinated biphenyls (PCBs) are industrial chemicals commonly found in food and building materials. PCBs are immunotoxic and may disturb the fetal programming of the immune and respiratory systems. We evaluated the association between maternal PCB exposure in indoor air and asthma, allergic rhinitis, atopic eczema, and respiratory infections in the offspring in the Health Effects of PCBs in Indoor Air (HESPAIR) cohort. This register-based study examined 7982 children born to mothers residing in two partially PCB contaminated residential areas in Greater Copenhagen before and/or during pregnancy. Children were included if their mothers at any point had lived in a contaminated or uncontaminated apartment in the period from 3.6 years prior to conception until the date of birth. PCB exposure was defined as mothers’ number of years in an apartment prior to birth of the child multiplied with the PCB concentration in indoor air based on air measurements. Information on the outcomes was retrieved from the Danish health registers from 1977 to 2018. We estimated adjusted hazard ratios using Cox regression. Our main analyses revealed no association between maternal exposure to PCBs in indoor air and any of the studied allergic and respiratory outcomes. Findings of sensitivity analyses were consistent with main analyses. While these findings may appear reassuring for the considerable number of people living or working in PCB contaminated indoor environments, they should be interpreted with caution due to the indirect measure of exposure, incomplete registration of diagnoses, and lack of supporting evidence from comparable studies.
母亲在室内空气中暴露于多氯联苯与儿童哮喘、过敏性鼻炎、特应性湿疹和呼吸道感染有关
多氯联苯是一种常见于食品和建筑材料中的工业化学品。多氯联苯具有免疫毒性,可能扰乱胎儿的免疫系统和呼吸系统。在“室内空气中多氯联苯的健康影响”(HESPAIR)队列研究中,我们评估了母亲在室内空气中多氯联苯暴露与后代哮喘、过敏性鼻炎、特应性湿疹和呼吸道感染之间的关系。这项基于登记的研究调查了居住在大哥本哈根两个部分多氯联苯污染住宅区的母亲在怀孕前和/或怀孕期间所生的7982名儿童。如果他们的母亲在怀孕前3.6年到出生之日的任何时候都住在受污染或未受污染的公寓里,他们的孩子就被包括在内。多氯联苯暴露的定义是母亲在孩子出生前在公寓里的年数乘以基于空气测量的室内空气中的多氯联苯浓度。从1977年至2018年的丹麦健康登记册中检索了有关结果的信息。我们使用Cox回归估计校正后的风险比。我们的主要分析显示,母亲暴露于室内空气中的多氯联苯与任何研究的过敏和呼吸结果之间没有关联。敏感性分析结果与主要分析结果一致。虽然这些发现可能会让相当多生活或工作在多氯联苯污染的室内环境中的人感到安心,但由于接触的间接测量,诊断的不完整登记以及缺乏可比较研究的支持证据,因此应谨慎解释这些发现。
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来源期刊
CiteScore
11.50
自引率
5.00%
发文量
151
审稿时长
22 days
期刊介绍: The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.
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