Cluster profiles of distressing psychotic-like experiences among children and associations with genetic risk, prenatal cannabis exposure, and social-environmental characteristics

IF 3.6 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2025-03-28 DOI:10.1016/j.schres.2025.03.034

Qingyue Yuan , Yinxian Chen , Ying Xu , Lina V. Dimitrov , Benjamin B. Risk , Elaine F. Walker , Anke Huels , Benson S. Ku

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引用次数: 0

Abstract

Background

Distressing psychotic-like experiences (PLEs) in children are associated with an increased risk for psychiatric disorders. Recent studies suggest that different domains of psychotic symptoms could be associated with distinct risk factors, but less is known about PLEs. This study clustered PLEs into subgroups and explored the genetic and environmental characteristics associated with these profiles.

Methods

Data from children (N = 11,854) recruited as part of the Adolescent Brain and Cognitive Development Study v5.1 assessed PLEs using 21-items from the Prodromal-Questionnaire-Brief Child Version. K-medoid clustering of PLEs was conducted among children with at least one distressing PLE item at baseline (n = 3155). Associations of polygenic risk scores for schizophrenia (PRS-SCZ) and social-environmental characteristics with PLE subgroups were estimated using generalized multinomial mixed models, adjusting for age, sex, race/ethnicity, parental education, income-to-needs ratio, and family history of psychosis.

Results

We identified three distressing PLE subgroups: hallucinatory-like (n = 1110), paranoid-like (n = 1229), and multiple PLE domains (n = 816). Compared to those without any distressing PLEs (n = 8699), those with hallucinatory-like PLE were more likely to have had prenatal cannabis exposure (Odds Ratio (OR) = 1.578, 95 % CI: 1.231–2.023); paranoid-like individuals had higher PRS-SCZ (OR = 1.080, 95 % CI: 1.001–1.166); those with multiple PLE domains participated in less physical activities (OR = 0.880, 95 % CI: 0.803–0.964). All groups were more likely to have experienced greater childhood adversity and worse school environments.

Conclusions

We found that those with different aspects of distressing PLEs had distinct and similar genetic and environmental characteristics. These results suggest that it may be important to consider the heterogeneity of PLE in conceptualizing the development of psychosis.

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.