Refresher training in administering intradermal BCG-vaccine increased BCG-scarring rates in rural Guinea-Bissau

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-03-25 DOI:10.1016/j.vaccine.2025.127039

Julie Odgaard Vedel , Oides Furtado , Laerte Lima Almeida , Jailson Sydenei Dias Martins , Sanne Møller Thysen , Andreas Møller Jensen , Igualdino Da Silva Borges , Ane Bærent Fisker

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引用次数: 0

Abstract

Background

A correct vaccination technique is important for developing BCG scars. Having a BCG scar is associated with lower mortality among BCG-vaccinated children.

Aim

To compare BCG-scar prevalences among children vaccinated before and after refresher training in BCG vaccination technique.

Methods

BCG-scar prevalence is assessed through a health and demographic surveillance system in rural Guinea-Bissau. In the context of a randomised trial, staff at health facilities in three regions (intervention area) received refresher training on BCG vaccination technique. In a fourth region (control area) no training was implemented. In logistic regression models, we compared scar prevalence among children vaccinated before and after the training.

Results

BCG-scar prevalence increased from 75 % to 92 % (odds ratio (OR) = 4.19, 95 %CI 2.92–6.01) in the intervention area and from 71 % to 78 % (OR = 1.43, 95 %CI 0.89–2.29) in the control area (p-value for same increase: <0.001).

Conclusion

BCG scarring rates increased after training in vaccination technique.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

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