Cs2CO3-Mediated Annulation of Cyclopropane-1,1-dicarbonitriles with o-Benzenediamines: Access to Substituted 2-Aminoquinoxalines

Abstract

The Cs₂CO₃-mediated formal (4 + 2) cascade annulation strategy for the synthesis of 2-aminoquinoxalines has been developed using D–A cyclopropanes and o-benzenediamines as the substrates. The protocol provides an efficient method of accessing a broad range of 2-aminoquinoxaline derivatives in good to excellent yields with good functional-group tolerance.