Surveillance and Genomic Evolution of Infectious Precocity Virus (IPV) from 2011 to 2024.

IF 3.8 3区医学 Q2 VIROLOGY

Viruses-Basel Pub Date : 2025-03-15 DOI:10.3390/v17030425

Chengyan Zhou, Guohao Wang, Qingqing Zhou, Fanzeng Meng, Shufang Liu, Jie Huang, Xuan Dong

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引用次数: 0

Abstract

Infectious precocity virus (IPV) poses a significant economic threat to the aquaculture industry by causing sexual precocity and slow growth in Macrobrachium rosenbergii. In this study, we conducted an in-depth investigation into the genetic evolution of IPV from 2011 to 2024 by collecting 31 IPV variants through epidemiological surveys and public databases, including 29 variants with complete genomic sequences. The phylogenetic analysis revealed that these complete genomic sequences clustered into two distinct phylogenetic clades as follows: the Southeast Asian clade and the Chinese clade. Nucleotide and protein variation analyses demonstrated a high degree of similarity, with nucleotide identity ranging from 98.5% to 100% and protein identity from 99.4% to 100%. Further analysis of protein variations within the putative coding region identified two distinct variation patterns. The average dN/dS ratio of 0.12 highlights the strong purifying selection acting on IPV, particularly on structural proteins. In conclusion, this study significantly expands the genomic database of IPV and provides valuable insights into its genetic evolution. These findings offer critical scientific evidence to enhance detection protocols and support sustainable M. rosenbergii aquaculture practices.

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2011 - 2024年传染性早熟病毒（IPV）监测与基因组进化

传染性早熟病毒（IPV）通过引起罗氏沼虾性早熟和生长缓慢，对水产养殖业造成了重大的经济威胁。本研究通过流行病学调查和公共数据库收集了31个IPV变异，其中29个变异具有完整的基因组序列，对2011 - 2024年IPV的遗传进化进行了深入研究。系统发育分析表明，这些完整的基因组序列可聚为两个不同的系统发育支系：东南亚支系和中国支系。核苷酸和蛋白质变异分析显示高度相似，核苷酸同源性在98.5% ~ 100%之间，蛋白质同源性在99.4% ~ 100%之间。对假设编码区域内蛋白质变异的进一步分析确定了两种不同的变异模式。平均dN/dS比为0.12，表明对IPV，特别是结构蛋白有很强的纯化选择作用。总之，本研究极大地扩展了IPV的基因组数据库，并为IPV的遗传进化提供了有价值的见解。这些发现为加强检测方案和支持可持续的罗氏沼虾养殖提供了重要的科学证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Viruses-Basel VIROLOGY-

CiteScore

7.30

自引率

12.80%

发文量

2445

审稿时长

1 months

期刊介绍： Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.