Curcumin Microemulsions: Influence of Compositions on the Dermal Penetration Efficacy.

IF 4.9 3区 医学 Q1 PHARMACOLOGY & PHARMACY
Muzn Alkhaldi, Soma Sengupta, Cornelia M Keck
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引用次数: 0

Abstract

Background/Objective: This study provided a comparison of the influence of each component of the microemulsion formulation and investigated the impact of varying concentrations of the microemulsion components on curcumin's ability to penetrate the skin using an ex vivo porcine ear model. Methods: Curcumin microemulsions with different compositions were prepared and analyzed for their physicochemical properties. The dermal penetration efficacy of curcumin was evaluated from the different formulations and compared with non-microemulsion formulations. Results: Findings proved that microemulsion formulations improve the dermal penetration efficacy for curcumin when compared with non-microemulsion formulations. The composition of the microemulsion affects the penetration efficacy of curcumin and increases with decreasing oil content and increasing surfactant and water content. The best penetration for curcumin is achieved with a microemulsion that contained 7.7 g of medium-chain triglycerides as the oil phase, 6.92 g of Tween® 80 and 62.28 g of ethanol as the surfactant mixture, and 23.1 g water. Conclusions: The present study provides a foundational basis for further development of different microemulsion formulations for enhancing the dermal penetration of poorly water-soluble active compounds.

姜黄素微乳:不同成分对透皮效果的影响。
背景/目的:本研究比较了微乳配方中各组分的影响,并利用离体猪耳模型研究了不同浓度微乳组分对姜黄素渗透皮肤能力的影响。方法:制备不同成分的姜黄素微乳,并对其理化性质进行分析。研究了姜黄素不同配方的透皮效果,并与非微乳配方进行了比较。结果:与非微乳制剂相比,微乳制剂提高了姜黄素的透皮效果。微乳液的组成影响姜黄素的渗透效果,并随着油含量的降低、表面活性剂和水含量的增加而增加。采用含有7.7 g中链甘油三酯作为油相,6.92 g Tween®80和62.28 g乙醇作为表面活性剂混合物,以及23.1 g水的微乳液,可以实现姜黄素的最佳渗透。结论:本研究为进一步开发不同的微乳液配方以提高难水溶性活性化合物的透皮性提供了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmaceutics
Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.90
自引率
11.10%
发文量
2379
审稿时长
16.41 days
期刊介绍: Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications,  and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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