From Motor Proteins to Oncogenic Factors: The Evolving Role of Kinesin Superfamily Proteins in Breast Cancer Development.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biotechnology Pub Date : 2025-03-27 DOI:10.1007/s12033-025-01428-2

Mohamed J Saadh, Hanan Hassan Ahmed, Radhwan Abdul Kareem, Muktesh Chandra, Mekha Monsi, Chakshu Walia, G V Siva Prasad, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Atheer Khdyair Hamad

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引用次数: 0

Abstract

The kinesin family of proteins (KIFs), known for their role as motor proteins, is integral to transporting cargo within cells along microtubule tracks, which is crucial for processes, such as cell division, differentiation, and intracellular communication. Increasing evidence shows that specific KIFs are overexpressed in breast cancer, a change linked to higher tumor aggression and poorer outcomes in patients. KIFs contribute to the cancerous characteristics of breast tumor cells through several mechanisms, including disruptions in spindle assembly during cell division, altered cell motility, and accelerated proliferation. This review summarizes current insights into KIFs' functions in breast cancer pathology and assesses their viability as therapeutic targets. By unraveling the complex involvement of KIFs, the article aims to open pathways for new therapeutic approaches in breast cancer and to promote further study into the cellular pathways that these proteins regulate.

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从运动蛋白到致癌因子：运动蛋白超家族蛋白在乳腺癌发展中的进化作用。

运动蛋白家族（KIFs）以其运动蛋白的作用而闻名，是沿着微管轨道在细胞内运输货物的组成部分，这对于细胞分裂、分化和细胞内通讯等过程至关重要。越来越多的证据表明，特定的kif在乳腺癌中过度表达，这一变化与更高的肿瘤侵袭性和患者较差的预后有关。KIFs通过多种机制促进乳腺肿瘤细胞的癌变特征，包括细胞分裂过程中纺锤体组装的破坏、细胞运动的改变和增殖的加速。本文综述了KIFs在乳腺癌病理中的功能，并评估了其作为治疗靶点的可行性。通过揭示KIFs的复杂参与，本文旨在为乳腺癌的新治疗方法开辟途径，并促进对这些蛋白质调节的细胞途径的进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biotechnology 医学-生化与分子生物学

CiteScore

4.10

自引率

3.80%

发文量

165

审稿时长

6 months

期刊介绍： Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.