Impact of Zika and Chikungunya Viruses on Spontaneous Abortions: Insights from a Reference Maternity Hospital.

IF 4.1 2区 生物学 Q2 MICROBIOLOGY
Anne Kerollen Pinheiro de Carvalho, Ana Cecília Ribeiro Cruz, Juarez Antônio Simões Quaresma, Arnaldo Jorge Martins Filho, Darlene de Brito Simith Durans, Orlando Pereira Amador Neto, Ligia do Socorro Oliveira de Lima, Norma Suely de Carvalho Fonseca Assunçao, Edna Cristina Santos Franco, Patrícia Brazão Cohen, Eliana Vieira Pinto da Silva
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Abstract

To investigate the association between miscarriage and ZIKV and CHIKV infection. The study population consisted of pregnant women who had miscarriages between 2015, 2016 and 2017, comprising a total of 30 women who were treated at the Santa Casa de Misericórdia do Pará Foundation (FSCMPA). The processed samples came from already paraffinized material containing placental and fetal remains, where they were tested with hematoxylin-eosin and immunohistochemistry for ZIKV and CHIKV. Regarding the sociodemographic, clinical and obstetric characteristics of the patients, they correspond to the age group between 20 and 29 years of age; of brown color; women who had abortions for the first time; miscarriages occurring in the first trimester of pregnancy; women belonging to the metropolitan region of Belém; diagnosed with incomplete abortion and who had undergone uterine curettage procedure. Regarding the histopathologic and immunohistochemical findings, an inflammatory infiltrate rich in neutrophils and lymphocytes, among others, was found in the endometrial fragments and chorionic membranes. In addition, placental areas consisting of edema, necrosis and hemorrhage were found. The study identified ZIKV and CHIKV in 40% (n = 12) of samples from spontaneous abortion specimens, and CHIKV was the most prevalent virus in the study, representing 36.11% of the total specimens, with reddish granular material in the cytoplasm of decidua cells and placental villi suggesting that the viruses may be present in these regions of the placenta.

寨卡病毒和基孔肯雅病毒对自然流产的影响:来自参考妇产医院的见解。
目的:探讨流产与寨卡病毒和CHIKV感染的关系。研究人群由2015年、2016年至2017年间流产的孕妇组成,共包括30名在Santa Casa de Misericórdia do parmpa基金会(FSCMPA)接受治疗的妇女。处理后的样本来自已经石蜡化的含有胎盘和胎儿残骸的材料,在那里用苏木精-伊红和免疫组织化学对它们进行了寨卡病毒和奇卡病毒的检测。关于患者的社会人口学、临床和产科特征,他们符合20至29岁的年龄组;褐色的:褐色的;第一次堕胎的妇女;流产发生在怀孕头三个月的流产;属于贝尔格莱德大都市区的妇女;诊断为不完全流产并做过子宫刮除手术者。在组织病理学和免疫组化方面,在子宫内膜碎片和绒毛膜中发现了富含中性粒细胞和淋巴细胞的炎症浸润。此外,发现胎盘区水肿、坏死和出血。该研究在40% (n = 12)的自然流产标本中发现了ZIKV和CHIKV,其中CHIKV是研究中最流行的病毒,占总标本的36.11%,在蜕膜细胞和胎盘绒毛的细胞质中有红色颗粒物质,表明病毒可能存在于胎盘的这些区域。
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来源期刊
Microorganisms
Microorganisms Medicine-Microbiology (medical)
CiteScore
7.40
自引率
6.70%
发文量
2168
审稿时长
20.03 days
期刊介绍: Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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