High-Density Lipoprotein Cholesterol Trajectories and Lung Function Decline: A Prospective Cohort Study.

IF 4.6 2区 医学 Q1 RESPIRATORY SYSTEM
Lung Pub Date : 2025-03-27 DOI:10.1007/s00408-025-00809-3
Byunghun Yoo, Sun Ho Jung, Soo Han Bae, Young Sam Kim, Chanho Lee
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Abstract

Purpose: Cholesterol regulation is essential to maintain pulmonary homeostasis. Studies suggest that increased high-density lipoprotein cholesterol (HDL-C) levels correlate with better lung function. However, the longitudinal association of HDL-C with lung function remains unknown. We aimed to analyze the long-term correlation of HDL-C with lung function decline in a population-based cohort study.

Methods: We included 7,652 participants from a prospective community-based cohort study in South Korea. Participants were categorized into five trajectory groups based on repeated HDL-C measurements. Generalized linear mixed models with random intercepts and slopes were used to examine the longitudinal relationship between HDL-C levels and lung function decline within these groups.

Results: In the five HDL-C trajectory group analyses, the very low HDL-C trajectory group (Group 1) showed faster declines in forced vital capacity (FVC) (-3.1 mL/year) and forced expiratory volume in one second (FEV1) (-3.1 mL/year) than the middle HDL-C group (Group 3, the reference group) did. The low HDL-C trajectory group (Group 2) also exhibited faster FVC (-1.5 mL/year) and FEV1 (-1.7 mL/year) declines than the middle HDL-C group; however, the estimated difference was smaller than that in Group 1. Faster lung function decline in the low HDL-C trajectory group was consistently observed even when the population was analyzed using three- or four-HDL-C trajectory groups instead of five.

Conclusion: Participants in the low HDL-C trajectory groups experienced a more rapid lung function decline over time than the reference groups, suggesting a negative longitudinal association between HDL-C and lung function decline.

高密度脂蛋白胆固醇轨迹与肺功能衰退:一项前瞻性队列研究。
目的:胆固醇调节对维持肺内环境平衡至关重要。研究表明,高密度脂蛋白胆固醇(HDL-C)水平的升高与肺功能的改善有关。然而,HDL-C与肺功能的纵向关联尚不清楚。在一项基于人群的队列研究中,我们旨在分析HDL-C与肺功能下降的长期相关性。方法:我们纳入了7652名来自韩国前瞻性社区队列研究的参与者。参与者根据重复的HDL-C测量分为五个轨迹组。采用随机截距和斜率的广义线性混合模型来检验这些组中HDL-C水平与肺功能下降之间的纵向关系。结果:在5个HDL-C轨迹组分析中,极低HDL-C轨迹组(1组)的用力肺活量(FVC) (-3.1 mL/年)和用力呼气量(FEV1) (-3.1 mL/年)下降速度快于中等HDL-C组(3组,参照组)。低HDL-C轨迹组(2组)的FVC (-1.5 mL/年)和FEV1 (-1.7 mL/年)的下降速度也比中等HDL-C组快;然而,与第一组相比,估计差异较小。低HDL-C轨迹组的肺功能下降速度更快,即使使用3个或4个HDL-C轨迹组而不是5个来分析人群时也是如此。结论:与对照组相比,低HDL-C轨迹组的参与者随着时间的推移经历了更快的肺功能下降,这表明HDL-C和肺功能下降之间存在负纵向关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lung
Lung 医学-呼吸系统
CiteScore
9.10
自引率
10.00%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.
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