Neurodevelopmental outcomes at age 3 years of preterm infants born at 22-31 weeks' gestation.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-03-26 DOI:10.1038/s41372-025-02268-3

Yumi Kono, Satoshi Kusuda, Toshihiko Nishida, Rintaro Mori, Katsuaki Toyoshima, Hatoko Sasaki, Naohiro Yonemoto, Atsushi Uchiyama, Masanori Fujimura

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引用次数: 0

Abstract

Objective: To evaluate neurodevelopmental outcomes of very preterm infants by gestational age (GA) using high follow-up rate data.

Study design: This secondary analysis included infants born before 32 weeks' gestation in 2012-2014 from the Improvement of NICU practices and Team Approach Cluster randomized controlled Trial (INTACT). The primary outcome was survival without moderate or severe neurodevelopmental impairment (NDI).

Results: Among 2722 infants, NICU survival rate was 96.5%, ranging 72.1-99.6% at 22-31 weeks. At age three years, 2336 (89.5% of 2610 survivors) were completely assessed; 303 had moderate NDI and 183 had severe NDI. Of these, the proportions of infants surviving without NDI increased with GA; 45.2% at 22 weeks, 57.5% at 23 weeks, 88.1% at 31 weeks.

Conclusion: Although survival without NDI varied by GA, more than half (55.0%, 83/151) of infants born at 22-23 weeks who survived to age three years were without neurodevelopmental sequelae.

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妊娠22-31周出生的3岁早产儿的神经发育结局。

目的：利用高随访率资料，评价胎龄极早产儿的神经发育结局。研究设计：该二级分析纳入2012-2014年妊娠32周前出生的新生儿，来自NICU实践改进和团队方法聚类随机对照试验（integrity）。主要终点是无中度或重度神经发育障碍（NDI）的生存期。结果：2722例新生儿NICU生存率为96.5%，22-31周生存率为72.1 ~ 99.6%。在3岁时，2336人（2610名幸存者中的89.5%）被完全评估；中度NDI 303例，重度NDI 183例。其中，没有NDI的婴儿存活率随着GA的增加而增加；22周45.2%，23周57.5%，31周88.1%。结论：尽管无NDI的生存率因GA而异，但在22-23周出生的存活至3岁的婴儿中，超过一半（55.0%,83/151）没有神经发育后遗症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.