A retrospective observational study of risk factors for postoperative meningitis following resection of meningioma.

IF 1.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-27 DOI:10.1177/03000605251327527
Yong Gu, Yuekang Zhang, Mengfei Zeng, Yangyun Han, Xiaodong Long
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引用次数: 0

Abstract

ObjectiveThis retrospective observational study aimed to explore the risk factors for postoperative meningitis following resection of meningioma.MethodsA total of 937 patients older than 18 years who underwent meningioma resection at the Department of Neurosurgery of three grade-A general hospitals in Sichuan Province between January 2021 and June 2024 were included. Basic patient information and perioperative variables were evaluated as risk factors for meningitis. Univariate and multivariate analyses were performed to identify the risk factors for postoperative meningitis.ResultsOverall, 47 (5.0%) of the 937 patients were infected with postoperative meningitis. Univariate analysis revealed that albumin level (<3.5 mg/dL; p = 0.017), preoperative hospitalization (median: 4 days; interquartile range: 2-6 days; p = 0.034), tumor location (skull base; p < 0.001), surgery duration (>3 h; p < 0.001), and bleeding volume during operation (≥400 mL; p < 0.001) were significantly associated with postoperative meningitis following resection of meningioma. The average postoperative hospital stay in the postoperative meningitis group was 14 days, whereas it was 6 days in the nonpostoperative meningitis group (p < 0.001). Furthermore, multivariate analysis showed that tumor location (skull base; p = 0.004; odds ratio = 2.914; 95% confidence interval: 1.395-6.091), surgery duration (>3 h; p = 0.006; odds ratio = 3.024; 95% confidence interval: 1.370-6.674), and bleeding volume during operation (p = 0.034; odds ratio = 2.057; 95% confidence interval: 1.056-4.006) were independent risk factors for postoperative meningitis following resection of meningioma.ConclusionTumor location (skull base), longer surgery duration (>3 h), and higher bleeding volume during operation (≥400 mL) were independent risk factors for postoperative meningitis following resection of meningioma. Moreover, postoperative meningitis was associated with a prolonged hospital stay. These findings can help identify patients with meningioma in need of special intervention to prevent postoperative meningitis and can help surgeons preoperatively identify the risk of postoperative meningitis for meningioma.

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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
555
审稿时长
1 months
期刊介绍: _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605
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