The Multifaceted Impact of Karrikin Signaling in Plants.

Abstract

Karrikins (KARs), produced during wildfires, are bioactive compounds that stimulate seed germination in fire-prone ecosystems and influence broader plant-environment interactions. These compounds act through the α/β hydrolase receptor KARRIKIN INSENSITIVE2 (KAI2), which perceives KARs as analogs of the hypothesized phytohormone KAI2 ligand (KL). KAR signaling shares molecular parallels with strigolactones (SLs), another class of butenolide plant hormones, and regulates diverse processes such as seedling development, root architecture, photomorphogenesis, and stress responses. Despite its multifaceted roles, the mechanistic basis of KAR-mediated regulation remains poorly understood. This review synthesizes insights into KAR signaling mechanisms, emphasizing recent advances in signal transduction pathways and functional studies. It also addresses key unresolved questions, including the identity of endogenous KL and the crosstalk between KARs and other hormonal networks. By elucidating these mechanisms, KAR-based strategies hold promises for enhancing crop resilience and sustainability, offering novel avenues for agricultural innovation in changing environments.