Prevalence and prognostic significance of malnutrition risk in patients with tuberculous meningitis.

IF 3 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Frontiers in Public Health Pub Date : 2025-03-12 eCollection Date: 2024-01-01 DOI:10.3389/fpubh.2024.1391821

Can Guo, Ke-Wei Liu, Jing Tong, Meng-Qiu Gao

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引用次数: 0

Abstract

Background: The residual risk of mortality or neurological disability is high in tuberculous meningitis (TBM), but there are not many effective treatments for TBM. Malnutrition is a modifiable risk factor for patients with tuberculous; however, the relationship between nutritional risk and neurological prognosis is not clear. In the present study, we aimed to explore the association between malnutrition risk and neurological outcome in patients with TBM.

Methods: A retrospective cohort study was conducted from December 2010 to January 2021. Malnutrition risks were evaluated by nutritional scales, including controlling nutritional status score (CONUT), geriatric nutritional risk index (GNRI), and prognostic nutritional index (PNI). The primary outcome was a poor recovery measured by a modified Rankin Scale (mRS) at 1-year follow-up. Malnutrition risk was estimated, and the association between malnutrition and follow-up outcome was analyzed.

Results: A total of 401 participants were analyzed in the study. According to CONUT, GNRI, and PNI, 299(74.56%), 231(57.61%), and 107(26.68%) patients were with malnutrition risk on admission. At 1-year follow-up, a total of 115 patients (28.67%) were with poor recovery. After adjustment for confounding factors, the association between moderate malnutrition (OR = 1.59, 95% CI 1.00-3.59, p = 0.050) and severe malnutrition (OR = 3.76, 95% CI 1.03-12.63, p = 0.049) was estimated by CONUT and was significantly associated with poor outcome. For each point increase in COUNT score (OR = 1.12, 95% CI 1.00-1.27, p = 0.059), the odds of poor functional recovery increased by 12%.

Conclusion: Malnutrition in TBM patients was related to an increased risk of poor neurological recovery in the long-term follow-up. Our study stressed the importance of assessing malnutrition in TBM patients.

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来源期刊

Frontiers in Public Health Medicine-Public Health, Environmental and Occupational Health

CiteScore

4.80

自引率

7.70%

发文量

4469

审稿时长

14 weeks

期刊介绍： Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice. Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.