Non-ocular biomarkers for early diagnosis of diabetic retinopathy by non-invasive methods.

IF 3.9 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Frontiers in Endocrinology Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI:10.3389/fendo.2025.1496851
Huaixue Gou, Juping Liu
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引用次数: 0

Abstract

Diabetic retinopathy (DR) is the predominant vision-threatening complication in individuals with diabetes mellitus. Timely diagnosis and intervention facilitate the prevention of diabetes-associated visual impairment. Classical imaging methods may prevent the timely detection of DR due to shortages of specialized facilities and retinal specialists, particularly in remote areas. In recent years, research on biomarkers related to DR has rapidly developed, playing an important role in risk assessment and early detection of the disease. Some ocular biomarkers from the vitreous body or aqueous humor were invasive, which hampered their application in clinical practice. Meanwhile, biomarkers based on omics were limited by their uneasily accessible use and complicated variables with a relatively low degree of reproducibility. As modern technology progresses, advanced non-ocular biomarkers of DR have established a comprehensive platform for the prompt identification of DR, independent of ophthalmic professionals or devices and accessible to non-ophthalmologists during community screenings. This review focuses on biomarkers derived from non-ocular sample sources, such as nailfold and skin, accessible through non-invasive methods, to reveal if they can be considered as an effective option for the early identification of DR by non-ophthalmologists in community screening initiatives.

非侵入性方法早期诊断糖尿病视网膜病变的非眼部生物标志物。
糖尿病视网膜病变(DR)是糖尿病患者最主要的视力威胁并发症。及时诊断和干预有助于预防糖尿病相关的视力损害。由于缺乏专门的设备和视网膜专家,特别是在偏远地区,传统的成像方法可能无法及时发现DR。近年来,与DR相关的生物标志物研究发展迅速,在疾病风险评估和早期发现中发挥着重要作用。一些来自玻璃体或房水的眼部生物标志物具有侵入性,阻碍了它们在临床中的应用。与此同时,基于组学的生物标志物易获取、变量复杂、可重复性相对较低,受到了限制。随着现代技术的进步,先进的DR非眼生物标志物为DR的快速识别建立了一个全面的平台,不依赖于眼科专业人员或设备,非眼科医生在社区筛查时也可以使用。本综述的重点是通过非侵入性方法获得的非眼部样本来源的生物标志物,如甲襞和皮肤,以揭示它们是否可以被视为社区筛查活动中非眼科医生早期识别DR的有效选择。
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来源期刊
Frontiers in Endocrinology
Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
5.70
自引率
9.60%
发文量
3023
审稿时长
14 weeks
期刊介绍: Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.
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