Functions of Drosophila Toll/NF-κB signaling in imaginal tissue homeostasis and cancer.

IF 4.6 2区 生物学 Q2 CELL BIOLOGY
Frontiers in Cell and Developmental Biology Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1559753
Fabienne Brutscher, Konrad Basler
{"title":"Functions of <i>Drosophila</i> Toll/NF-κB signaling in imaginal tissue homeostasis and cancer.","authors":"Fabienne Brutscher, Konrad Basler","doi":"10.3389/fcell.2025.1559753","DOIUrl":null,"url":null,"abstract":"<p><p>The Toll/NF-κB pathway plays a central role in patterning the <i>Drosophila</i> embryo and in orchestrating the innate immune response against microbial infections. Both discoveries were associated with a Nobel Prize award and led to the recognition of the Toll-like receptor pathway in mammals, which has significant implications for diseases. Recent discoveries have revealed that the Toll/NF-κB pathway also maintains epithelial homeostasis of imaginal tissues during development: local Toll/NF-κB signaling activity monitors internal cellular fitness, and precancerous mutant cells can trigger systemic Toll/NF-κB pathway activation. However, this signaling can be exploited in diseases like cancer, in which Toll/NF-κB signaling is often co-opted or subverted. Various models have been proposed to explain how Toll/NF-κB signaling contributes to different types of cancer. Here we provide an overview of the functions of Toll/NF-κB signaling in imaginal tissue homeostasis with a focus on their misuse in pathological contexts, particularly their significance for tumor formation.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1559753"},"PeriodicalIF":4.6000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936955/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cell and Developmental Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/fcell.2025.1559753","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The Toll/NF-κB pathway plays a central role in patterning the Drosophila embryo and in orchestrating the innate immune response against microbial infections. Both discoveries were associated with a Nobel Prize award and led to the recognition of the Toll-like receptor pathway in mammals, which has significant implications for diseases. Recent discoveries have revealed that the Toll/NF-κB pathway also maintains epithelial homeostasis of imaginal tissues during development: local Toll/NF-κB signaling activity monitors internal cellular fitness, and precancerous mutant cells can trigger systemic Toll/NF-κB pathway activation. However, this signaling can be exploited in diseases like cancer, in which Toll/NF-κB signaling is often co-opted or subverted. Various models have been proposed to explain how Toll/NF-κB signaling contributes to different types of cancer. Here we provide an overview of the functions of Toll/NF-κB signaling in imaginal tissue homeostasis with a focus on their misuse in pathological contexts, particularly their significance for tumor formation.

果蝇Toll/NF-κB信号在组织稳态和肿瘤中的作用。
Toll/NF-κB通路在果蝇胚胎的模式化和对微生物感染的先天免疫反应中发挥核心作用。这两项发现都与诺贝尔奖有关,并导致人们认识到哺乳动物中的toll样受体途径,这对疾病具有重要意义。最近的研究发现,Toll/NF-κB通路在发育过程中也维持了成像组织的上皮稳态:局部Toll/NF-κB信号活性监测细胞内部适应性,癌前突变细胞可触发全身性Toll/NF-κB通路激活。然而,这种信号可以在癌症等疾病中被利用,在这些疾病中,Toll/NF-κB信号经常被吸收或破坏。已经提出了各种模型来解释Toll/NF-κB信号如何促进不同类型的癌症。在这里,我们概述了Toll/NF-κB信号在组织稳态中的功能,并重点介绍了它们在病理背景下的误用,特别是它们在肿瘤形成中的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
9.70
自引率
3.60%
发文量
2531
审稿时长
12 weeks
期刊介绍: Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信