Atherogenic index of plasma and periodontitis in non-dyslipidemic adults: a nationwide study.

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Investigations Pub Date : 2025-03-27 DOI:10.1007/s00784-025-06277-6

Tae-Gu Kang, Na-Yeong Kim, Sang-Min Lee, Ki-Ho Chung

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引用次数: 0

Abstract

Background: This study investigated the association between atherogenic index of plasma (AIP)-related indices and periodontal diseases in adults without dyslipidemia using healthcare big data from Korea National Health & Nutrition Examination Survey (KNHANES).

Methods: This cross-sectional study analyzed data from 16,343 adults in the 2010-2018 KNHANES. Periodontal status was assessed using the Community Periodontal Index (CPI), while AIP-related indices, including AIP, triglycerides (TG), and high-density lipoprotein cholesterol (HDL), were evaluated. Statistical analyses included chi-square tests and t-tests for group comparisons, multivariate logistic regression to calculate odds ratios (ORs) for periodontitis risk, and receiver operating characteristic (ROC) curve analysis to assess diagnostic accuracy.

Results: Higher AIP-related indices (excluding HDL) were associated with an increased risk of periodontitis, while lower HDL levels also correlated with higher disease prevalence. (p < 0.0001). The AIP adjusted with waist-to-height ratio (AIP*WHtR) exhibited the highest diagnostic accuracy among all indices analyzed, with the highest area under the ROC curve (AUC), whereas HDL showed the lowest predictive value.

Conclusions: AIP-related indices were significantly associated with periodontitis in adults without dyslipidemia, with higher AIP-related indices linked to an increased risk of periodontitis. Among these, AIP*WHtR exhibited the highest diagnostic accuracy. However, due to the cross-sectional study design, causality cannot be determined. Thus, longitudinal studies are required to validate the predictive value of AIP-related indices for periodontitis risk.

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非血脂异常成人血浆和牙周炎的动脉粥样硬化指数：一项全国性研究。

背景：本研究利用韩国国家健康与营养调查（KNHANES）的医疗保健大数据，调查无血脂异常的成人血浆粥样硬化指数（AIP）相关指数与牙周病的关系。方法：本横断面研究分析了2010-2018年KNHANES中16,343名成年人的数据。使用社区牙周指数（CPI）评估牙周状况，同时评估AIP相关指标，包括AIP、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL）。统计分析采用卡方检验和t检验进行组间比较，采用多变量logistic回归计算牙周炎风险的优势比（ORs），采用受试者工作特征（ROC）曲线分析评估诊断准确性。结果：较高的aip相关指数（不包括HDL）与牙周炎的风险增加相关，而较低的HDL水平也与较高的疾病患病率相关。结论：在无血脂异常的成年人中，aip相关指数与牙周炎显著相关，aip相关指数越高，患牙周炎的风险越高。其中，AIP*WHtR的诊断准确率最高。然而，由于横断面研究设计，无法确定因果关系。因此，需要进行纵向研究来验证aip相关指标对牙周炎风险的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.