Association of systemic inflammatory biomarkers with ocular disease: a large population-based cross-sectional study.

IF 2.8 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-03-26 DOI:10.1186/s40001-025-02473-y

Xue Wang, Haitao Jiang, Can Zhang

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引用次数: 0

Abstract

Background: The aim of this study was to explore the association of systemic inflammatory biomarkers (systemic immune-inflammation (SII) index and systemic inflammatory response index (SIRI)) with the prevalence of ocular disease in the general population of the United States (U.S.).

Methods: We conducted a cross-sectional study of subjects in the National Health and Nutrition Examination Survey 2005-2008 years. For the analysis of the association of SII index, and SIRI with the prevalence of ocular disease (glaucoma, cataract, age-related macular degeneration (ARMD), and diabetic retinopathy), the restricted cubic spline (RCS) plot, multivariable logistic regression models, and subgroup analysis were performed.

Results: There was a total of 5377 individuals. As shown by the RCS plot, SII index and SIRI were linked with ARMD risk in a U-shaped pattern. Additionally, the SII index and SIRI were linearly positive with glaucoma and cataract. Finally, the risk of diabetic retinopathy was associated with the L-shaped and N-shaped curves of the SII index and SIRI, respectively.

Conclusions: Two new systemic inflammatory biomarkers, SII index and SIRI, are closely related to the risk of eye disease. There are different associations between SII index and different ocular diseases. This should raise more concerns and lead to better prevention strategies for systemic inflammation.

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系统性炎症生物标志物与眼部疾病的关联：一项基于人群的大型横断面研究

背景：本研究的目的是探讨全身性炎症生物标志物（全身性免疫炎症（SII）指数和全身性炎症反应指数（SIRI））与美国普通人群眼部疾病患病率的关系。方法：对2005-2008年全国健康与营养调查对象进行横断面研究。为了分析SII指数和SIRI与眼部疾病（青光眼、白内障、年龄相关性黄斑变性（ARMD）和糖尿病视网膜病变）患病率的关系，采用了限制性三次样条（RCS）图、多变量logistic回归模型和亚组分析。结果：共5377人。RCS图显示，SII指数和SIRI与ARMD风险呈u型关系。此外，SII指数和SIRI与青光眼和白内障呈线性正相关。最后，糖尿病视网膜病变的风险分别与SII指数的l型曲线和SIRI的n型曲线相关。结论：两种新的全身性炎症生物标志物SII指数和SIRI与眼病风险密切相关。SII指数与不同眼病有不同的相关性。这应该引起更多的关注，并导致更好的系统性炎症预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.