Feasibility and effects of remotely supervised aerobic training and resistance training in older adults with mild cognitive impairment: a pilot three-arm randomised controlled trial.

IF 5.3 3区医学 Q1 PSYCHIATRY

General Psychiatry Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI:10.1136/gpsych-2024-101858

Xiuxiu Huang, Shifang Zhang, Xiaoyan Zhao, Xinrui Li, Fulian Bao, Yue Lan, Yuyao Zhang, Ran An, Bei Li, Fang Yu, Yongan Sun, Qiaoqin Wan

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引用次数: 0

Abstract

Abstract:

Background: Evidence on the effects of different exercise interventions on cognitive function is insufficient.

Aims: To evaluate the feasibility and effects of remotely supervised aerobic exercise (AE) and resistance exercise (RE) interventions in older adults with mild cognitive impairment (MCI).

Methods: This study is a 6-month pilot three-arm randomised controlled trial. Eligible participants (n=108) were recruited and randomised to the AE group, RE group or control (CON) group with a 1:1:1 ratio. Interventions were delivered at home with remote supervision. We evaluated participants' global cognition, memory, executive function, attention, physical activity levels, physical performance and muscle strength of limbs at baseline, 3 months (T1) and 6 months (T2) after randomisation. A linear mixed-effects model was adopted for data analyses after controlling for covariates. Tukey's method was used for adjusting for multiple comparisons. Sensitivity analyses were performed after excluding individuals with low compliance rates.

Results: 15 (13.89%) participants dropped out. The median compliance rates in the AE group and RE group were 67.31% and 93.27%, respectively. After adjusting for covariates, the scores of the Alzheimer's Disease Assessment Scale-Cognitive subscale in the AE group decreased by 2.04 (95% confidence interval (CI) -3.41 to -0.67, t=-2.94, p=0.004) and 1.53 (95% CI -2.88 to -0.17, t=-2.22, p=0.028) points more than those in the CON group at T1 and T2, respectively. The effects of AE were still significant at T1 (estimate=-1.70, 95% CI -3.20 to -0.21, t=-2.69, p=0.021), but lost statistical significance at T2 after adjusting for multiple comparisons. As for executive function, the Stroop time interference in the RE group decreased by 11.76 s (95% CI -21.62 to -1.90, t=-2.81, p=0.015) more than that in the AE group at T2 after Tukey's adjustment. No other significant effects on cognitive functions were found.

Conclusions: Both remotely supervised AE and RE programmes are feasible in older adults with MCI. AE has positive effects on global cognition, and RE improves executive function.

Trial registration number: ChiCTR2100045582.

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远程监督有氧训练和阻力训练对轻度认知障碍老年人的可行性和效果：一项三组随机对照试验。

摘要：背景：关于不同运动干预对认知功能影响的证据不足。目的：评价远程监督有氧运动（AE）和阻力运动（RE）干预老年人轻度认知障碍（MCI）的可行性和效果。方法：本研究是一项为期6个月的三组随机对照试验。招募符合条件的参与者（n=108），按1:1:1的比例随机分为AE组、RE组或对照组（CON）。干预措施在家中进行，并有远程监督。我们评估了受试者在基线、随机化后3个月（T1）和6个月（T2）的整体认知、记忆、执行功能、注意力、身体活动水平、身体表现和四肢肌肉力量。控制协变量后，采用线性混合效应模型进行数据分析。Tukey的方法用于调整多重比较。在排除低依从率的个体后进行敏感性分析。结果：15名（13.89%）参与者退出。AE组和RE组的中位依从率分别为67.31%和93.27%。调整协变量后，AE组在T1和T2分别比CON组降低2.04分（95%置信区间(CI) -3.41 ~ -0.67, t=-2.94, p=0.004）和1.53分（95% CI -2.88 ~ -0.17, t=-2.22, p=0.028）。AE的影响在T1时仍然显著（估计值=-1.70,95% CI = -3.20 ~ -0.21, t=-2.69, p=0.021），但经多重比较调整后，在T2时失去统计学意义。在执行功能方面，经Tukey调整后T2时，RE组Stroop时间干扰较AE组下降11.76 s （95% CI -21.62 ~ -1.90, t=-2.81, p=0.015）。没有发现对认知功能的其他显著影响。结论：远程监督AE和RE方案在老年MCI患者中都是可行的。AE对整体认知有积极影响，RE对执行功能有改善作用。试验注册号：ChiCTR2100045582。

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来源期刊

General Psychiatry 医学-精神病学

CiteScore

21.90

自引率

2.50%

发文量

848

期刊介绍： General Psychiatry (GPSYCH), an open-access journal established in 1959, has been a pioneer in disseminating leading psychiatry research. Addressing a global audience of psychiatrists and mental health professionals, the journal covers diverse topics and publishes original research, systematic reviews, meta-analyses, forums on topical issues, case reports, research methods in psychiatry, and a distinctive section on 'Biostatistics in Psychiatry'. The scope includes original articles on basic research, clinical research, community-based studies, and ecological studies, encompassing a broad spectrum of psychiatric interests.