Genetic susceptibility to essential hypertension in the Chinese han population: a study on GAB1, GAB2, and GAB3 gene polymorphisms.

IF 2 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

BMC Cardiovascular Disorders Pub Date : 2025-03-26 DOI:10.1186/s12872-025-04669-w

Jiajie Xiong, Lijun Zhu, Wanjun Zhang, Yurui Zhou, Yue Yu, Miao Xu, Pu Dong, Zhengmei Fang, WeiWei Chang, Yan Chen, Yingshui Yao, Yuelong Jin

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引用次数: 0

Abstract

Background: This study aims to examine the association between single nucleotide gene polymorphisms (SNPs) of GAB1, GAB2, and GAB3 and the genetic susceptibility to essential hypertension in the Chinese Han population. The findings of this research will contribute to understanding the underlying causes of hypertension.

Methods: A community-based sampling survey was conducted in two towns in the south of Jiangsu Province to investigate the correlation between gene polymorphisms and essential hypertension. The study included a total of 2119 cases of hypertension and 2317 healthy controls, with an average follow-up period of 10.75 years. The genotypes of seven tagging SNPs (GAB1 rs300893 and rs11936966, GAB2 rs7107174, rs2450135, and rs3740677, GAB3 rs3813455 and rs5987015) were analyzed.

Results: Regression analysis showed that after multifactor correction, only GAB1 rs300893 dominant model was statistically associated with the risk of hypertension among 7 SNPs locis before Bonferroni correction. Subgroup analysis showed that there were associations between specific SNPS and the risk of hypertension in different subgroups, but after Bonferroni correction, these associations were no longer statistically significant. In the follow-up study, Cox proportional hazard regression analysis showed that there was no significant association between the seven SNPs locis and the risk of hypertension. However, subgroup analyses suggest that some gene variants are associated with a reduced or increased risk of hypertension in specific populations. After Bonferroni correction, the addition model of GAB2 rs7107174 was still statistically significant in the specific stratified analysis. Plasma GAB1, GAB2, and GAB3 mRNA expression showed no significant difference between the hypertensive group and the control group.

Conclusion: These findings provide additional support for the genetic role of GAB1, GAB2 and GAB3 in hypertension and blood pressure regulation.

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来源期刊

BMC Cardiovascular Disorders CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

3.50

自引率

0.00%

发文量

480

审稿时长

1 months

期刊介绍： BMC Cardiovascular Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the heart and circulatory system, as well as related molecular and cell biology, genetics, pathophysiology, epidemiology, and controlled trials.