Jovian Wan, Soo-Bin Kim, Hugues Cartier, Sebastien Garson, Konstantin Frank, Diala Haykal, Kyu-Ho Yi
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引用次数: 0
Abstract
Background: Androgenetic alopecia (AGA) is a prevalent condition that significantly impacts patients' psychological well-being and quality of life. Traditional treatments, such as minoxidil and finasteride, have limited efficacy and undesirable side effects. Exosome therapy, which uses extracellular vesicles to promote tissue regeneration, offers a promising alternative. This study evaluates the effectiveness of exosome therapy combined with microneedling (MTS) for treating AGA.
Objective: To assess the efficacy of exosome therapy in promoting hair regrowth in patients with AGA following microneedling treatment.
Methods: This prospective, open-label study included 16 male patients aged 36-45 years with mild to moderate AGA. Microneedling was performed on the scalp followed by the application of exosome topical therapy (ZISHEL XOMAGE, Zishel Bio Inc., Seoul, Republic of Korea). Hair density and patient satisfaction were evaluated through clinical assessments and photographic documentation at 1, 3, 6, and 12 months after treatment. Side effects were also monitored.
Results: At the 12-month follow-up, the average increase in hair density was 35 hairs/cm2, with a standard deviation of 6.5 hairs/cm2. Baseline hair densities ranged from 75 hairs/cm2 to 95 hairs/cm2, with improvements observed in all patients. Patient satisfaction was high, with 80% of participants reporting noticeable improvements in hair regrowth and 87% indicating satisfaction or high satisfaction with the results. Mild side effects, including scalp tenderness and slight irritation, were reported but resolved within 48 hours.
Conclusion: Exosome therapy, in combination with microneedling, offers a promising non-surgical treatment for AGA, demonstrating significant improvements in hair regrowth and patient satisfaction. Further studies with larger samples and longer follow-up periods are needed to confirm the long-term efficacy of this approach.
Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com/00266 .
背景：雄激素性脱发（AGA）是一种常见病，严重影响患者的心理健康和生活质量。传统的治疗方法，如米诺地尔和非那雄胺，疗效有限，而且有不良的副作用。外泌体疗法，利用细胞外囊泡促进组织再生，提供了一个有前途的选择。本研究评估外泌体联合微针治疗AGA的有效性。目的：探讨外泌体治疗对AGA患者微针治疗后毛发再生的促进作用。方法：这项前瞻性、开放标签研究纳入了16例年龄36-45岁的轻至中度AGA男性患者。在头皮上进行微针，然后应用外泌体局部治疗（ZISHEL XOMAGE, ZISHEL Bio Inc., Seoul, Republic of Korea）。在治疗后1、3、6和12个月，通过临床评估和照片记录来评估头发密度和患者满意度。副作用也被监测。结果：随访12个月，毛发密度平均增加35根/cm2，标准差为6.5根/cm2。基线头发密度从75根/平方厘米到95根/平方厘米不等，所有患者均观察到改善。患者满意度很高，80%的参与者报告头发再生的明显改善，87%的人表示对结果满意或高度满意。轻微的副作用，包括头皮压痛和轻微刺激，报告，但在48小时内解决。结论：外泌体联合微针治疗AGA是一种很有前景的非手术治疗方法，在毛发再生和患者满意度方面有显著改善。进一步的研究需要更大的样本和更长的随访期来证实这种方法的长期疗效。证据等级iv：本刊要求作者为每篇文章指定一个证据等级。有关这些循证医学评级的完整描述，请参阅目录或在线作者说明https://www.springer.com/00266。
期刊介绍：
Aesthetic Plastic Surgery is a publication of the International Society of Aesthetic Plastic Surgery and the official journal of the European Association of Societies of Aesthetic Plastic Surgery (EASAPS), Società Italiana di Chirurgia Plastica Ricostruttiva ed Estetica (SICPRE), Vereinigung der Deutschen Aesthetisch Plastischen Chirurgen (VDAPC), the Romanian Aesthetic Surgery Society (RASS), Asociación Española de Cirugía Estética Plástica (AECEP), La Sociedad Argentina de Cirugía Plástica, Estética y Reparadora (SACPER), the Rhinoplasty Society of Europe (RSE), the Iranian Society of Plastic and Aesthetic Surgeons (ISPAS), the Singapore Association of Plastic Surgeons (SAPS), the Australasian Society of Aesthetic Plastic Surgeons (ASAPS), the Egyptian Society of Plastic and Reconstructive Surgeons (ESPRS), and the Sociedad Chilena de Cirugía Plástica, Reconstructiva y Estética (SCCP).
Aesthetic Plastic Surgery provides a forum for original articles advancing the art of aesthetic plastic surgery. Many describe surgical craftsmanship; others deal with complications in surgical procedures and methods by which to treat or avoid them. Coverage includes "second thoughts" on established techniques, which might be abandoned, modified, or improved. Also included are case histories; improvements in surgical instruments, pharmaceuticals, and operating room equipment; and discussions of problems such as the role of psychosocial factors in the doctor-patient and the patient-public interrelationships.
Aesthetic Plastic Surgery is covered in Current Contents/Clinical Medicine, SciSearch, Research Alert, Index Medicus-Medline, and Excerpta Medica/Embase.
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