Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease.

IF 8.1 1区 医学 Q1 CLINICAL NEUROLOGY
Verena Dzialas, Gérard N Bischof, Kathrin Möllenhoff, Alexander Drzezga, Thilo van Eimeren
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Abstract

Objective: Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study has established a longitudinal relationship between the DaT signal decline and the motor symptom increase, potentially due to neglected factors such as brain regions, disease laterality, and symptom subtypes, which this study addresses.

Methods: This cohort study included participants who met the Movement Disorder Society (MDS) criteria for PD, with longitudinal imaging and clinical data from the Parkinson's Progression Markers Initiative Database. Linear mixed model analyses were used to investigate the relationship between the DaT signal decline and the motor symptom severity increase over time. We hypothesized that a decline in putaminal DaT availability in the less affected hemisphere would be associated with increasing contralateral motor symptoms, measured by the Unified Parkinson's Disease Rating Scale (UPDRS). Additional models explored the effects of different brain regions (caudate and putamen), symptom categories (MDS UPDRSIII score with and without tremor items), and disease onset laterality (left or right hemisphere).

Results: We included 719 participants (443 male patients and 276 female patients; mean age = 62.2 ± 9.5 years) with 1,981 available data points. As hypothesized, we observed a significant association between the decrease in the less affected putaminal DaT signal and motor symptom increase in the contralateral body side, independent of including or excluding tremor scores.

Interpretation: Our findings support the use of repetitive DaT imaging for objectively monitoring PD progression. This could facilitate personalized disease tracking, subtyping, and intervention testing in the future. ANN NEUROL 2025.

多巴胺转运体成像作为帕金森病的客观监测生物标志物。
目的:尽管多巴胺转运蛋白(DaT)成像是一种有价值的诊断性生物标志物,但很少有研究调查其在客观监测帕金森病(PD)患者疾病进展中的应用。到目前为止,还没有研究建立DaT信号下降与运动症状增加之间的纵向关系,这可能是由于被忽视的因素,如大脑区域、疾病侧边性和症状亚型,而本研究解决了这些因素。方法:该队列研究纳入了符合运动障碍协会(MDS) PD标准的参与者,并使用纵向成像和帕金森进展标志物倡议数据库的临床数据。采用线性混合模型分析,探讨了随着时间的推移,DaT信号下降与运动症状严重程度增加之间的关系。通过统一帕金森病评定量表(UPDRS)测量,我们假设受影响较轻的半球的皮层数据可用性的下降与对侧运动症状的增加有关。其他模型探讨了不同脑区域(尾状核和壳核)、症状类别(MDS UPDRSIII评分有无震颤项目)和疾病发病侧性(左或右半球)的影响。结果:我们纳入了719名参与者(443名男性患者和276名女性患者;平均年龄= 62.2±9.5岁),1981个数据点。正如假设的那样,我们观察到受影响较小的壳层DaT信号的减少与对侧身体运动症状的增加之间存在显著的关联,与包括或排除震颤评分无关。解释:我们的研究结果支持使用重复数据成像客观监测PD进展。这可以促进个性化的疾病跟踪、亚型分型和未来的干预测试。Ann neurol 2025。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Neurology
Annals of Neurology 医学-临床神经学
CiteScore
18.00
自引率
1.80%
发文量
270
审稿时长
3-8 weeks
期刊介绍: Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.
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