Hesperidin protects the cerebral cortex of albino Wistar rats from the toxic effects of palmitic acid and preserves neurotransmitters-associated enzymes.

IF 1.6 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Ahmed S Ahmed, Liju S Mathew, Marwa M Madi, Omaima K Docmac, Hoda A Ibrahim, Pallav Sengupta, Rasha A Eldeeb, Ehab M Hantash
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引用次数: 0

Abstract

Palmitic acid (PMA) is abundantly present in substantial quantities within palm oil and manifests neurodegenerative propensities. Conversely, the ingestion of Hesperidin (HSD) is correlated with a reduction in inflammatory markers and mediators. This investigation was meticulously devised to scrutinize the protective potential of HSD against the deleterious repercussions of PMA administration on the cerebral cortex. A cohort comprising forty albino Wistar rats was stratified into four groups, each receiving supplements of HSD and PMA. Remarkably, HSD was observed to fortify the histological framework of the cerebral cortex subsequent to PMA exposure, concurrently diminishing the percentage of apoptotic cells. Furthermore, HSD upregulated the levels of antioxidant markers, preserved the levels of neurotransmitter-associated enzymes, and downregulated the expression of inflammation-regulating genes. In conclusion, PMA exerts toxic effects on the cerebral cortex of albino Wistar rats, leading to increased apoptosis and neuroinflammation, thereby reducing brain cholinergic activity. HSD was found to attenuate the cerebral cortex content of MPO, 5-NTD, ROS, MDA, and NF-κB. Additionally, it elevated the cerebral cortex content of antioxidants and anti-inflammatory markers, thereby shielding it from the deleterious effects of PMA.

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来源期刊
Biotechnic & Histochemistry
Biotechnic & Histochemistry 生物-生物工程与应用微生物
CiteScore
3.40
自引率
6.20%
发文量
46
审稿时长
6-12 weeks
期刊介绍: Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.
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