{"title":"Psychotropic-induced weight gain and telomere length","authors":"Y. W. Francis Lam Pharm.D., FCCP","doi":"10.1002/pu.31299","DOIUrl":null,"url":null,"abstract":"<p>Research suggests that shortening of telomeres, protective cap-like structures at the ends of chromosomes, as well as inflammation, are associated with decreased cellular lifespan, and as such have been implicated in several age-related medical conditions (Gavia-García et al., 2021). A meta-analysis has reported an association between shorter telomere length and several psychiatric conditions, including anxiety, bipolar disorder, depression, post-traumatic stress disorder, and psychosis (Darrow et al., 2016).</p>","PeriodicalId":22275,"journal":{"name":"The Brown University Psychopharmacology Update","volume":"36 5","pages":"2-3"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Brown University Psychopharmacology Update","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/pu.31299","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Research suggests that shortening of telomeres, protective cap-like structures at the ends of chromosomes, as well as inflammation, are associated with decreased cellular lifespan, and as such have been implicated in several age-related medical conditions (Gavia-García et al., 2021). A meta-analysis has reported an association between shorter telomere length and several psychiatric conditions, including anxiety, bipolar disorder, depression, post-traumatic stress disorder, and psychosis (Darrow et al., 2016).
研究表明，端粒缩短、染色体末端的保护性帽状结构以及炎症与细胞寿命缩短有关，因此与几种与年龄相关的疾病有关（Gavia-García等人，2021）。一项荟萃分析报告了端粒长度较短与几种精神疾病之间的关联，包括焦虑、双相情感障碍、抑郁症、创伤后应激障碍和精神病（Darrow et al., 2016）。
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