Efficacy of topical sildenafil formulations in enhancing wound healing outcomes: a narrative review

IF 1.8 4区 医学 Q3 DERMATOLOGY
Maryam Shahrokhi, Fatemeh Naghibi, Sabah Moraghebi, Parmida Khorrami, Habibeh Mashayekhi-sardoo
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引用次数: 0

Abstract

Sildenafil, a major phosphodiesterase type 5 (PDE5) inhibitor, is particularly known for treating erectile dysfunction. It has been suggested as a promising therapeutic medication for accelerating wound healing. This study aimed to summarize the efficacy of different formulations and dosages of sildenafil in enhancing wound healing, focusing on its formulations, dosages, and mechanisms of action. The study used relevant keywords to review studies involving animal models and human patients. No time limitation was considered in the current study. The outcomes measured included re-epithelization, vascularization, collagen formation, and overall healing efficacy. Topical sildenafil formulations indicated significant improvements in wound closure, vascularization, and collagen regeneration in skin wounds. A combination of platelet-rich plasma (PRP) and sildenafil increased skin wound healing. Different concentrations (topical 2% and 5% formulation, and 13 mg/kg orally) were useful, with specific dosages showing significant improvements in healing biomarkers. The underlying mechanisms of sildenafil for accelerating wound healing are increasing nitric oxide (NO) levels and collagen synthesis. Moreover, sildenafil triggers angiogenesis, and fibroblast migration and contributes to skin tissue repair and regeneration. Topical sildenafil can be a promising drug for increasing wound healing, with different formulations and dosages illustrating efficacy in improving healing outcomes. Since sildenafil is a cost-efficient, and readily available drug with few side effects, we suggest further research to optimize its use in clinical settings.

Graphical abstract

局部西地那非制剂在提高伤口愈合结果方面的疗效:叙述性回顾
西地那非是一种主要的磷酸二酯酶5型(PDE5)抑制剂,尤其以治疗勃起功能障碍而闻名。它被认为是一种很有前途的加速伤口愈合的治疗药物。本研究旨在总结不同剂型和剂量的西地那非促进创面愈合的疗效,重点介绍其剂型、剂量和作用机制。本研究使用相关关键词对涉及动物模型和人类患者的研究进行综述。本研究未考虑时间限制。测量的结果包括再上皮化、血管化、胶原形成和整体愈合效果。局部西地那非制剂在伤口愈合、血管化和皮肤伤口胶原蛋白再生方面有显著改善。富血小板血浆(PRP)和西地那非联合使用可促进皮肤伤口愈合。不同浓度(局部2%和5%配方,以及13mg /kg口服)是有用的,特定剂量显示愈合生物标志物的显着改善。西地那非促进伤口愈合的潜在机制是增加一氧化氮(NO)水平和胶原合成。此外,西地那非还能促进血管生成和成纤维细胞迁移,有助于皮肤组织修复和再生。局部西地那非是一种很有希望的促进伤口愈合的药物,不同的配方和剂量说明了改善愈合结果的功效。由于西地那非是一种成本效益高、易于获得且副作用少的药物,我们建议进一步研究以优化其在临床环境中的使用。图形抽象
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来源期刊
CiteScore
4.10
自引率
3.30%
发文量
30
审稿时长
4-8 weeks
期刊介绍: Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.
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