The effect of rosacea on neurodegenerative and neuropsychiatric diseases: a two-sample Mendelian randomization study

IF 1.8 4区 医学 Q3 DERMATOLOGY
Xiangjun Hu, Dandan Shen, Hong Cai, Zhangren Yan
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Abstract

This study aimed to explore the potential causal relationships between rosacea and Parkinson’s disease, Alzheimer’s disease, anxiety disorders, and depression with MR analysis. Genetic data for rosacea and the four neurodegenerative and neuropsychiatric disorders were sourced from GWAS databases. After completing stringent quality control procedures, SNPs meeting significance thresholds were selected as IVs. Our primary statistical analysis was conducted by IVW approach. To investigate the robustness of results, heterogeneity tests, sensitivity analyses, and pleiotropy assessments were conducted. Reverse MR analyses were subsequently carried out to further substantiate the causal relationships. The present study discovered a positive correlation between rosacea and an elevated risk of depression (OR = 1.0015, 95% CI = 1.0002–1.0027, P = 0.02). There is no causal evidence to support a connection between rosacea and Parkinson’s disease, Alzheimer’s disease, or anxiety disorders. Reverse MR analyses indicated no causal associations between these four disorders and the risk of rosacea. The findings reveal that individuals with rosacea may have an elevated risk of depression.

酒渣鼻对神经退行性和神经精神疾病的影响:一项双样本孟德尔随机研究
本研究旨在通过磁共振分析探讨酒渣鼻与帕金森病、阿尔茨海默病、焦虑症和抑郁症之间的潜在因果关系。酒渣鼻和四种神经退行性和神经精神疾病的遗传数据来自GWAS数据库。在完成严格的质量控制程序后,选择符合显著性阈值的snp作为iv。我们的主要统计分析采用IVW方法进行。为了研究结果的稳健性,进行了异质性检验、敏感性分析和多效性评估。随后进行反向磁共振分析以进一步证实因果关系。本研究发现酒渣鼻与抑郁症风险升高呈正相关(OR = 1.0015, 95% CI = 1.0002-1.0027, P = 0.02)。没有因果证据支持酒渣鼻与帕金森病、阿尔茨海默病或焦虑症之间的联系。反向磁共振分析表明,这四种疾病与酒渣鼻的风险之间没有因果关系。研究结果表明,患有酒渣鼻的人患抑郁症的风险更高。
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来源期刊
CiteScore
4.10
自引率
3.30%
发文量
30
审稿时长
4-8 weeks
期刊介绍: Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.
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