Recent applications and advancement of conductive hydrogels in biosensing, bioelectronics and bioengineering

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-03-27 DOI:10.1007/s00604-025-07123-y

Shi-Yu Chen, Tao Feng, Zeng-Qiang Wu, Ning Bao

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Abstract

Conductive hydrogels (CHs) are characterized by their distinctive three-dimensional (3D) network architecture enhanced by physically entangled or chemically cross-linked polymer chains. In recent years, these materials have garnered significant scientific interest owing to their unique combination of inherent electrical conductivity and remarkable capability to transduce external stimuli into measurable electronic signals. The immense potentials of those CHs in a number of applications catalyzed this review to summarize their specific properties and applications in biosensing, bioelectronics and bioengineering. Firstly, the preparation and unique properties of CHs were summarized, including mechanical properties, adhesion properties, self-healing capabilities, conductivity, biodegradability, and biocompatibility. We demonstrated tremendous potentials of CHs in the real world by showcasing their broad applications in biosensing (such as nerve sensing, strain sensing, glucose sensing, tumor sensing, temperature sensing, and environmental sensing), bioelectronics and bioengineering (such as treatment of cardiac and wound healing). Finally, by presenting current challenges and issues of CHs, future potential research directions were outlined for their applications in the study of biosensing, bioelectronics and bioengineering.

Graphical Abstract

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导电性水凝胶在生物传感、生物电子学和生物工程中的应用与进展

导电水凝胶（CHs）的特点是其独特的三维（3D）网络结构，通过物理纠缠或化学交联的聚合物链增强。近年来，这些材料由于其独特的固有导电性和将外部刺激转化为可测量的电子信号的显着能力的组合而获得了重大的科学兴趣。本文综述了该类化合物在生物传感、生物电子学和生物工程等方面的特性及其应用。首先，综述了CHs的制备方法及其独特的性能，包括力学性能、粘附性能、自愈能力、导电性、生物降解性和生物相容性。我们通过展示其在生物传感（如神经传感、应变传感、葡萄糖传感、肿瘤传感、温度传感和环境传感）、生物电子学和生物工程（如心脏和伤口愈合的治疗）方面的广泛应用，展示了CHs在现实世界中的巨大潜力。最后，通过分析当前生物传感器面临的挑战和存在的问题，展望了生物传感器在生物传感、生物电子学和生物工程等领域的应用前景。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.