Liposome of a synergistic combination of HDP-mimicking polymer and rifampicin for treating bacterial infections in aquaculture via oral administration

IF 6.8 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Science China Materials Pub Date : 2025-03-03 DOI:10.1007/s40843-024-3254-y

Haowen Yu (, ), Luhang Chen (, ), Yueming Wu (, ), Wenhui Dai (, ), Minzhang Chen (, ), Yuan Chen (, ), Longqiang Liu (, ), Jiangzhou Wang (, ), Xinqi Huang (, ), Kang Chen (, ), Runhui Liu (, )

{"title":"Liposome of a synergistic combination of HDP-mimicking polymer and rifampicin for treating bacterial infections in aquaculture via oral administration","authors":"Haowen Yu \n (, ), Luhang Chen \n (, ), Yueming Wu \n (, ), Wenhui Dai \n (, ), Minzhang Chen \n (, ), Yuan Chen \n (, ), Longqiang Liu \n (, ), Jiangzhou Wang \n (, ), Xinqi Huang \n (, ), Kang Chen \n (, ), Runhui Liu \n (, )","doi":"10.1007/s40843-024-3254-y","DOIUrl":null,"url":null,"abstract":"<div><p>The extensive use of antibiotics in high-density aquaculture has accelerated the emergence of antibiotic-resistant bacteria. The presence of antibiotics in water and soil, and their transmission through the food chain exacerbate the pressures associated with antibiotic resistance, posing a significant threat to human health. Despite this challenge and serious issue, effective alternatives to antibiotics remain lacking. In this study, we report a potent synergistic effect between an HDP-mimicking polymer, <sup>DL</sup>Lys<sub>90</sub>-BLG<sub>10</sub>, and rifampicin against <i>Vibrio</i> species. This synergistic combination substantially reduces the required dosage of rifampicin, thereby mitigating the risk of antibiotic resistance development and the release of rifampicin into water and soil. Furthermore, we developed a cell-penetrating peptide-modified liposome system that can co-encapsulate <sup>DL</sup>Lys<sub>90</sub>-BLG<sub>10</sub> and rifampicin, which exerts potent antibacterial activity against <i>Vibrio</i> both <i>in vitro</i> and <i>in vivo</i>, while maintaining bio-compatibility. Additionally, oral administration of CPP-Lip@Syn showed effective control of <i>Vibrio</i> infections. This strategy opens new avenues in exploring antibiotic alternatives in aquaculture and implies potential applications in aquaculture.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":"68 4","pages":"1259 - 1270"},"PeriodicalIF":6.8000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s40843-024-3254-y","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

The extensive use of antibiotics in high-density aquaculture has accelerated the emergence of antibiotic-resistant bacteria. The presence of antibiotics in water and soil, and their transmission through the food chain exacerbate the pressures associated with antibiotic resistance, posing a significant threat to human health. Despite this challenge and serious issue, effective alternatives to antibiotics remain lacking. In this study, we report a potent synergistic effect between an HDP-mimicking polymer, ^DLLys₉₀-BLG₁₀, and rifampicin against Vibrio species. This synergistic combination substantially reduces the required dosage of rifampicin, thereby mitigating the risk of antibiotic resistance development and the release of rifampicin into water and soil. Furthermore, we developed a cell-penetrating peptide-modified liposome system that can co-encapsulate ^DLLys₉₀-BLG₁₀ and rifampicin, which exerts potent antibacterial activity against Vibrio both in vitro and in vivo, while maintaining bio-compatibility. Additionally, oral administration of CPP-Lip@Syn showed effective control of Vibrio infections. This strategy opens new avenues in exploring antibiotic alternatives in aquaculture and implies potential applications in aquaculture.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Science China Materials Materials Science-General Materials Science

CiteScore

11.40

自引率

7.40%

发文量

949

期刊介绍： Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.