Y. B. Zhang, S. W. Pan, M. Zhang, X. S. Guo, J. F. Wang, M. Bu
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引用次数: 0
Abstract
A series of novel betulin-28-thiazole ester derivatives were designed, synthesized, and subsequently evaluated for their anticancer activity. Among these compounds, 3β-hydroxylup-20(29)-en-28-yl 3-(5-carboxy-4-methylthiazol-2-yl)-1-methylpyridin-1-ium iodide demonstrated the most potent anticancer activity against A549 cells, with an IC50 value of 2.24 µM, being 11.23-fold more potent than betulin. Meanwhile, 3β-hydroxylup-20(29)-en-28-yl 3-(5-carboxy-4-methylthiazol-2-yl)-1-methylpyridin-1-ium iodide displayed exceptional water solubility, being 20.15-fold higher than that of betulin. In summary, these data identified 3β-hydroxylup-20(29)-en-28-yl-3-(5-carboxy-4-methylthiazol-2-yl)-1-methylpyridin-1-ium iodide as a promising lead compound that warrants further investigation of its anticancer properties.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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