Aggregation-induced emission-based covalent-organic framework fluorescent probes for clinical detection of aluminum and daily prevention of Alzheimerʼs disease by naked-eye

IF 10.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Science China Chemistry Pub Date : 2024-11-07 DOI:10.1007/s11426-024-2303-x

Yun Zhao, Enpeng Xi, Ziwei Wang, Qi Ding, Kangning Liu, Jinxing Zhu, Xuhan Wu, Yiling Xie, Fuming Yang, Nan Gao, Hanjun Sun, Yajie Yang, Ye Yuan, Guangshan Zhu

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引用次数: 0

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disease and a major threat to human health worldwide. The association between aluminum exposure and AD has been widely reported. Owing to the ubiquitous presence of aluminum in daily life, aluminum exposure can easily occur whenever and wherever possible. Thus, a rapid and sensitive reagent for detecting aluminum and assist in AD daily prevention for potential AD patient population is extremely needed. However, existing aluminum detection methods rely on precise instruments, which are impractical for household use. Herein, a series of aggregation-induced emission-based covalent-organic framework (AIE-COF) fluorescent probes has been designed with progressively tuned sizes and screened for aluminum detection. Among them, COF-N2 was found to have the highest response towards aluminum specifically, with a fluorescence intensity change of 19.14 times before and after chelation, which could determine the aluminum concentration by naked eye. Then, the molecular mechanism of COF-N2 fluorescence changes was explained and COF-N2 was used for both diagnose the aluminum distribution in various organs of APP/PS1 transgenic mice and quickly determine the aluminum content in daily necessities. The use of AIE-COF probes for aluminum detection provides a promising avenue for developing aluminum related AD clinical diagnosis and daily prevention tools.

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.