{"title":"Synthesis, Characterization, and Molecular Docking Studies of Chalcone-Based Imidazole Derivatives as Potential Antioxidant Agents","authors":"R. J. Kamel, N. A. Abdul-Rida","doi":"10.1134/S1070363225600043","DOIUrl":null,"url":null,"abstract":"<p>This study focuses on the synthesis of novel organic compounds with potential antioxidant activity. The intermediate hydroxychalcone derivative was synthesized via Claisen-Schmidt condensation and then reacted with chloroacetamide derivatives to produce the target compounds. The biological activity of these compounds was evaluated in vitro by DPPH assay and theoretically using molecular docking. The results obtained support the tested compounds’ importance in free radical scavenging which showed promising inhibitory potential against free radical. The high inhibition percentages of these compounds (up to 88.8% at a concentration of 500 μM) compared to ascorbic acid may be due to their structural properties attracting to the free radicals.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"95 3","pages":"715 - 721"},"PeriodicalIF":0.9000,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363225600043","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
This study focuses on the synthesis of novel organic compounds with potential antioxidant activity. The intermediate hydroxychalcone derivative was synthesized via Claisen-Schmidt condensation and then reacted with chloroacetamide derivatives to produce the target compounds. The biological activity of these compounds was evaluated in vitro by DPPH assay and theoretically using molecular docking. The results obtained support the tested compounds’ importance in free radical scavenging which showed promising inhibitory potential against free radical. The high inhibition percentages of these compounds (up to 88.8% at a concentration of 500 μM) compared to ascorbic acid may be due to their structural properties attracting to the free radicals.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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