Pillararene based supramolecular nanoplatform for endoplasmic reticulum-targeting type I photodynamic and NO gas therapy

IF 6.8 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Science China Materials Pub Date : 2025-03-05 DOI:10.1007/s40843-024-3268-6

Shaoqi Xie (, ), Chang Liu (, ), Yue Cao (, ), Jiachen Xia (, ), Bing Lu (, )

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引用次数: 0

Abstract

The development of tumor-targeted multimodality therapy is an important strategy to improve the curative effects of cancer treatment. It is critical to construct such a platform that can perfectly integrate these functional entities into one. Herein, we designed a phenyl sulfonamide-modified pillararene WP5-PEG-BSA. WP5-PEG-BSA can be used to construct endoplasmic reticulum (ER)-targeting nanocarriers. Then NO donor S-nitroso-N-acetyl-D-penicillamine (SNAP) and the newly designed photosensitizer DPP-DMATPE were loaded into the nanocarriers via different paths. Under laser irradiation, DPP-DMATPE exhibited excellent type I photodynamic activity, while SNAP can release NO under the action of glutathione. The formed nanodrugs BSA-DPP/SNAP exhibited outstanding ER-targeting and high lethality towards tumor cells as well as biocompability. What’s even more worth saying is that BSA-DPP/SNAP performed well even in hypoxic tumor cells. The final experimental results in vivo again confirmed the good therapeutic effects of BSA-DPP/SNAP. As a result, a supramolecular nanoplatform that realizes highly efficient ER-targeting type I photodynamic and NO gas cancer therapy was constructed.

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来源期刊

Science China Materials Materials Science-General Materials Science

CiteScore

11.40

自引率

7.40%

发文量

949

期刊介绍： Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.