Predictive value in memory evaluation of the temporal mesial afterdischarges induced by electrical stimulations in stereoelectroencephalography

IF 3.2 2区心理学 Q1 BEHAVIORAL SCIENCES

Cortex Pub Date : 2025-03-18 DOI:10.1016/j.cortex.2025.02.014

Adrien Bénard , Dragos-Mihai Maliia , Pascale Trébon , Yves Sahler , Arnaud Biraben , Anca Nica

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引用次数: 0

Abstract

This study evaluates patients' performances on memory tasks during the afterdischarges (ADs) induced by electrical stimulation (ES) in stereoelectroencephalography (SEEG) and compares the results with those of neuropsychological assessment (NPA) in memory evaluation and their predictive value for postoperative memory decline. We reviewed the SEEGs recorded between 1998 and 2022, with bilateral mesial temporal lobe implantations. During the mesial temporal ADs, the patients were evaluated with: the recall of presented objects, the recognition among other objects, and the presence of disorientation in space or time. These performances were compared to the NPA memory scores. For patients who underwent surgery, we evaluated the predictive value of the performance during unilateral mesial temporal AD on postsurgical memory outcomes and compared it with the prediction based on NPA. A total of 65 patients were included. A correlation approaching significance was observed between the NPA results and the performance during the ADs in the non-dominant hemisphere for a recall threshold of .33 (p = .05) and in the dominant side for a recall threshold of .25 (p = .06). For the operated patients, the predictive value of performance during AD for postoperative memory outcome was significant for AD ipsilateral to the surgery at a threshold of .75 (p = .028). It appears that memory performance during mesial temporal AD tends to correlate with the NPA results and can be an additional tool for pre-operative memory assessment. Further dedicated studies are required to validate its more reliable use in surgery.

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立体脑电图对电刺激引起的颞内膜放电记忆评价的预测价值

本研究利用立体脑电图（SEEG）评价电刺激后放电（ES）患者在记忆任务上的表现，并与神经心理评估（NPA）在记忆评价方面的结果及其对术后记忆衰退的预测价值进行比较。我们回顾了1998年至2022年间记录的双侧内侧颞叶植入的SEEGs。在中颞期ad期间，对患者进行评估：对所呈现物体的回忆，对其他物体的识别以及在空间或时间上的定向障碍的存在。将这些表现与NPA记忆分数进行比较。对于接受手术的患者，我们评估了单侧内侧颞叶AD期间的表现对术后记忆结果的预测价值，并将其与基于NPA的预测进行了比较。共纳入65例患者。非优势半球的NPA结果与ad期间的表现呈显著相关，回忆阈值为0.33 (p = 0.05)，优势半球的NPA结果与ad期间的表现呈显著相关，回忆阈值为0.25 （p = 0.06）。对于手术患者，AD期间的表现对手术同侧AD患者术后记忆结果的预测价值显著，阈值为0.75 （p = 0.028）。中期颞叶痴呆期间的记忆表现倾向于与NPA结果相关，并且可以作为术前记忆评估的额外工具。需要进一步的专门研究来验证其在手术中的更可靠的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cortex 医学-行为科学

CiteScore

7.00

自引率

5.60%

发文量

250

审稿时长

74 days

期刊介绍： CORTEX is an international journal devoted to the study of cognition and of the relationship between the nervous system and mental processes, particularly as these are reflected in the behaviour of patients with acquired brain lesions, normal volunteers, children with typical and atypical development, and in the activation of brain regions and systems as recorded by functional neuroimaging techniques. It was founded in 1964 by Ennio De Renzi.