Castor oil-based molecularly imprinted nanoparticles for the detection of cardiac troponin I: Towards green molecularly imprinted nanoreceptors

IF 4.1 Q1 CHEMISTRY, ANALYTICAL
Pinar Cakir Hatir , Alice Marinangeli , Alessandra Maria Bossi , Gokhan Cayli
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Abstract

Molecularly imprinted polymers (MIPs) are synthetic materials that selectively recognize target molecules, offering cost-effective and stable alternatives to antibodies. While MIP nanoparticles are ideal for biomedical applications for their high surface area and their biomolecule-compatible size, traditional monomers used in their synthesis can pose issues in biocompatibility. This study presents a sustainable approach to MIP nanoparticle production using acrylated methyl ricinoleate (AMR), a functional monomer derived from castor oil. These "GreenNanoMIPs" were designed to recognize cardiac troponin I (cTnI), a key biomarker for cardiovascular events. The nanoparticles, with an average size of 81 nm, exhibited exceptional homogeneity in suspension, with a low PDI value of 0.064, and outstanding stability, as no changes in particle size distribution or PDI were observed even after one year. GreenNanoMIPs did recognize the entire cTnI protein thorough the epitope approach. Furthermore, GreenNanoMIPs were successfully used for the detection of the cTnI biomarker directly in serum. The study highlights the potential of eco-friendly, biocompatible MIPs for applications in diagnostics, drug delivery, and environmental sensing.

Abstract Image

蓖麻油基分子印迹纳米颗粒检测心肌肌钙蛋白I:迈向绿色分子印迹纳米受体
分子印迹聚合物(MIPs)是一种选择性识别目标分子的合成材料,为抗体提供了成本效益高且稳定的替代品。虽然MIP纳米颗粒因其高表面积和生物分子相容性尺寸而成为生物医学应用的理想选择,但在其合成中使用的传统单体可能会带来生物相容性问题。本研究提出了一种可持续的方法,使用丙烯酸甲基蓖麻油酸酯(AMR)生产MIP纳米颗粒,AMR是一种从蓖麻油中提取的功能单体。这些“greennanomip”旨在识别心脏肌钙蛋白I (cTnI),这是心血管事件的关键生物标志物。纳米颗粒的平均尺寸为81 nm,在悬浮液中表现出优异的均匀性,PDI值较低,为0.064,并且即使在一年后也没有观察到颗粒大小分布和PDI的变化,具有出色的稳定性。GreenNanoMIPs通过表位方法识别了整个cTnI蛋白。此外,GreenNanoMIPs成功地用于直接检测血清中的cTnI生物标志物。该研究强调了生态友好的生物相容性MIPs在诊断、药物输送和环境传感方面的应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Talanta Open
Talanta Open Chemistry-Analytical Chemistry
CiteScore
5.20
自引率
0.00%
发文量
86
审稿时长
49 days
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