Sensitive and selective detection of cancer biomarkers with molecularly imprinted biosensors

IF 4.1 Q1 CHEMISTRY, ANALYTICAL
Sibel Büyüktiryaki
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引用次数: 0

Abstract

Accurate and reliable detection of cancer biomarkers plays a pivotal role in early diagnosis, disease progression monitoring, and effective treatment strategies. Molecularly imprinted polymers (MIPs), with their high selectivity and stability, have emerged as powerful tools for biomarker detection. This review explores the fundamental principles of MIPs and their tailored synthesis for biological markers. Special emphasis is placed on integrating MIPs with analytical techniques such as optical and electrochemical sensing platforms. Moreover, it highlights their success in real biological matrices and addresses the challenges and opportunities for developing advanced solutions. Finally, the review addresses challenges and future directions, emphasizing the critical role of MIP technology in achieving ultra-sensitive, cost-effective, and portable diagnostic solutions. This review aims to highlight the potential of MIP-based sensors for the selective and sensitive detection of cancer biomarkers and to serve as a guide for researchers in the field.
利用分子印迹生物传感器灵敏、选择性地检测癌症生物标志物
准确可靠的癌症生物标志物检测在早期诊断、疾病进展监测和有效的治疗策略中起着关键作用。分子印迹聚合物(MIPs)以其高选择性和高稳定性,已成为生物标志物检测的有力工具。本文综述了MIPs的基本原理及其用于生物标记物的定制合成。特别强调的是集成MIPs与分析技术,如光学和电化学传感平台。此外,它强调了他们在真实生物基质中的成功,并解决了开发先进解决方案的挑战和机遇。最后,回顾了挑战和未来的方向,强调了MIP技术在实现超灵敏、低成本和便携式诊断解决方案中的关键作用。本综述旨在强调基于mip的传感器在选择性和敏感检测癌症生物标志物方面的潜力,并为该领域的研究人员提供指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Talanta Open
Talanta Open Chemistry-Analytical Chemistry
CiteScore
5.20
自引率
0.00%
发文量
86
审稿时长
49 days
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