Petasis reaction: An expeditious generation of multiple stereogenic centres

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-03-22 DOI:10.1016/j.tetlet.2025.155548

Ayon Sengupta , Chhanda Mukhopadhyay

引用次数: 0

Abstract

In view of the versatility of the Petasis reaction (PR) for the synthesis of different organic compounds with enormous applications in biology and pharmaceutics, this short review is intended to focus on the Petasis and associated reactions that produces multiple (more than one) stereogenic centres. The reactions were organised and categorized on the basis of the number of stereocenters centres generated in the overall process. The multicomponent reactions with dual PR sequences, asymmetric PRs, and build/couple/pair (B/C/P) strategies involving PR/IMDA(intramolecular Diels–Alder)/RCM(ring-closing metathesis)/ROM(ring-opening metathesis) cascades were captured in this review.

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Petasis反应：快速生成多个立体中心

鉴于Petasis反应（PR）在合成不同有机化合物方面的多功能性，在生物学和制药领域有着广泛的应用，本文将重点介绍产生多个（不止一个）立体中心的Petasis及其相关反应。根据整个过程中产生的立体中心的数量对反应进行了组织和分类。本文综述了双PR序列、非对称PR序列和构建/偶对（B/C/P）策略的多组分反应，包括PR/IMDA（分子内Diels-Alder）/RCM（闭环复分解）/ROM（开环复分解）级联反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.