Gut microbiota and metabolome signatures in obese and normal-weight patients with colorectal tumors

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-03-13 DOI:10.1016/j.isci.2025.112221

Marta La Vecchia , Michela Giulia Clavenna , Marika Sculco , Gloria Sala , Denise Marradi , Elettra Barberis , Soni Joseph , Marta Mellai , Nico Pagano , Renzo Boldorini , Barbara Azzimonti , Elisa Bona , Edoardo Pasolli , Flavia Prodam , Carlotta Sacerdote , Daniela Ferrante , Emilia Ghelardi , Marcello Manfredi , Anna Aspesi , Irma Dianzani

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引用次数: 0

Abstract

Here, we aim to improve our understanding of various colorectal cancer (CRC) risk factors (obesity, unhealthy diet, and gut microbiota/metabolome alteration), analyzing 120 patients with colon polyps, divided in normal-weight (NW) or overweight/obese (OB). Dietary habits data (validated EPIC questionnaires) revealed a higher consumption of processed meat among OB vs. NW patients. Both mucosa-associated microbiota (MAM) on polyps and lumen-associated microbiota (LAM) analyses uncovered distinct bacterial signatures in the two groups. Importantly, we found an enrichment of the pathogenic species Finegoldia magna in MAM of OB patients, regardless of their polyp stage. We observed distinct mucosal-associated metabolome signatures, with OB patients showing increased pyroglutamic acid and reduced niacin levels, and performed microbiota-metabolome integrated analysis. These findings support a model where different risk factors may contribute to tumorigenesis in OB vs. NW patients, highlighting the potential impact of processed meat consumption and F. magna on CRC development among OB patients.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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