Effect of different extraction methods on the structural analysis, water solubility, and bioactivity of hemp polysaccharides-cannabidiol complexes

IF 4.9 2区化学 Q2 CHEMISTRY, PHYSICAL

Colloids and Surfaces A: Physicochemical and Engineering Aspects Pub Date : 2025-03-24 DOI:10.1016/j.colsurfa.2025.136729

Hang Li , Bo-Wen Li , Yuan Zhu , Zi-Yi Guo , Qing-Sheng Zhao , Bing Zhao

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引用次数: 0

Abstract

The wide application of cannabidiol (CBD) is restricted by its poor water solubility. Natural polysaccharides are promising carrier materials for insoluble natural products. In this study, to analyze the effect of hemp polysaccharides (HPs) complexation on the water solubility of CBD, two hemp polysaccharide samples, HUEHP and UHEP were firstly prepared by high-pressure ultrasonic-assisted extraction and ultrasonic extraction. The physicochemical properties of UHEP and HUEHP were analyzed and the results showed that HUEHP had a higher molecular weight compared to UEHP. Subsequently, the complexes UEHP-CBD and HUEHP-CBD were prepared. Multiple characterization results indicated that HUEHP had better complexation effect and the formation of the complexes was mainly attributed to hydrogen bonding interaction, accompanied by the amorphization of CBD which was beneficial to its solubilization. Moreover, the solubility of CBD in UEHP-CBD and HUEHP-CBD was increased to 4.220 and 3.473 μg/mL respectively, attributed to the complexation with HPs. The interaction between HPs and CBD improved the antioxidant activity of the complexes. This study demonstrated the application potential of UEHP-CBD and HUEHP-CBD.

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来源期刊

Colloids and Surfaces A: Physicochemical and Engineering Aspects 化学-物理化学

CiteScore

8.70

自引率

9.60%

发文量

2421

审稿时长

56 days

期刊介绍： Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena. The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.