High-dose vitamin D supplementation in pregnancy ameliorates obesity-induced increase in maternal IL-1β level without affecting obesity-induced increase in IL-6 and MCP

IF 2.7 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2025-03-24 DOI:10.1016/j.jsbmb.2025.106742

Helena H. Andersen , Matilde K. Andersen , Krista Agathe Bossow , Anna Louise Vestergaard , Pinar Bor , Agnete Larsen

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引用次数: 0

Abstract

Background

Maternal and placental inflammatory activity is carefully regulated during pregnancy and changes in inflammatory status are associated with pregnancy complications and health deficits in the offspring including adverse effects on neurodevelopment. Overweight/obesity is associated with chronic inflammation, thereby contributing to adverse effects. Disturbingly, overweight and obesity are highly prevalent among pregnant women worldwide. Vitamin D (vitD) possess immunomodulatory effects and is believed to support healthy pregnancy. Endocrinological societies recommend empiric vitD supplementation in pregnancy but there is no consensus on the minimal supplementation dose

Methods

An adjacent study to GRAVIT-D (no. NCT04291313, ClinicalTrial.gov), a double-blinded randomized trial investigating the clinical benefits of increasing vitD supplementation in pregnancy from 400IU to 3600IU/day from gestational week 11–16 onwards. In a subgroup, (n = 156), multiplex ELISA targeting third-semester serum levels of IL-1β, IL-6, IL-10, TNFα, MCP-1, and IL-17A was performed. Inflammation signals were correlated with the vitD dose given, subsequently analysing the effect of vitD in relation to the pre-pregnancy body mass index (BMI) within each treatment arm comparing the inflammatory response in WHO-defined BMI groups, < 25, 25–30 and > 30 kg/m².

Main Results

High pre-pregnancy BMI was associated with increased IL6 and MCP1 in both the 400IU and the 3600 IU exposed group. IL1β levels increased with BMI if using a 400IU/day supplement. High dose vitD supplementation ameliorated BMI effects on IL1β.

Conclusion and Perspectives

Increased vitD supplementation during pregnancy may ameliorate some overweight/obesity-induced inflammatory activity. Further studies are needed to determine the vitD need in pregnancies complicated by obesity and overweight.

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妊娠期补充大剂量维生素D可改善肥胖诱导的母体IL-1β水平升高，但不影响肥胖诱导的IL-6和MCP升高

妊娠期间母体和胎盘的炎症活动受到严格调控，炎症状态的变化与妊娠并发症和后代的健康缺陷有关，包括对神经发育的不良影响。超重/肥胖与慢性炎症有关，从而导致不良反应。令人不安的是，超重和肥胖在世界各地的孕妇中非常普遍。维生素D （vitD）具有免疫调节作用，被认为有助于健康怀孕。内分泌学会建议在怀孕期间经验性补充维生素d，但对于最低补充剂量尚无共识。NCT04291313, ClinicalTrial.gov)，一项双盲随机试验，调查妊娠期从妊娠11-16周开始将维生素d补充剂从400IU /天增加到3600IU/天的临床益处。在一个亚组中（n = 156），采用针对第三学期血清IL-1β、IL-6、IL-10、TNFα、MCP-1和IL-17A水平的多重ELISA检测。炎症信号与给予的维生素d剂量相关，随后分析维生素d对每个治疗组孕前体重指数（BMI）的影响，比较who定义的BMI组的炎症反应，<； 25,25 - 30和>； 30 kg/m2。在400IU和3600iu暴露组中，高孕前BMI与IL6和MCP1升高有关。如果每天补充400IU， il - 1β水平会随着BMI的增加而增加。高剂量维生素d补充剂可改善BMI对il - 1β的影响。结论和观点孕期增加维生素d的补充可能会改善一些超重/肥胖引起的炎症活动。需要进一步的研究来确定合并肥胖和超重的孕妇对维生素d的需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Steroid Biochemistry and Molecular Biology 生物-内分泌学与代谢

CiteScore

8.60

自引率

2.40%

发文量

113

审稿时长

46 days

期刊介绍： The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental and theoretical developments in areas related to steroids including vitamin D, lipids and their metabolomics. The Journal publishes a variety of contributions, including original articles, general and focused reviews, and rapid communications (brief articles of particular interest and clear novelty). Selected cutting-edge topics will be addressed in Special Issues managed by Guest Editors. Special Issues will contain both commissioned reviews and original research papers to provide comprehensive coverage of specific topics, and all submissions will undergo rigorous peer-review prior to publication.