Photocatalytic Three-Component Radical Sulfonarylation of Alkenes: Preparation of γ-Keto-Sulfone-Substituted Oxindoles

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-03-16 DOI:10.1021/acs.joc.4c0317410.1021/acs.joc.4c03174

Fei Chen*, Jun-Ya Guo, Yun-Hong Jia, Jingze Li, Yi-Jie Zhu, Yu-Xin Lai, Yi-Nan Zhang, Si-Yu Tian, Shu-Man Wang, Yang Zheng* and Yunhe Lv,

引用次数: 0

Abstract

A photocatalytic radical sulfonarylation of N-arylacrylamides via a three-component cascade cyclopropyl alcohol ring opening/sulfur dioxide insertion/sulfonyl radical addition/cyclization sequence has been developed. This method employs cyclopropyl alcohols as the precursors of β-carbonyl alkyl radicals and Na₂S₂O₅ as a cheap source of sulfur dioxide. By using this cascade procedure, a wide variety of γ-keto-sulfone-substituted oxindoles were facilely synthesized.

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光催化烯烃三组分自由基磺酰化：γ-酮砜取代氧吲哚的制备

通过环丙醇开环/二氧化硫插入/磺酰基自由基加成/环化的三组分级联顺序，建立了n -芳基丙烯酰胺的光催化自由基磺酰化反应。该方法采用环丙醇作为β-羰基烷基自由基的前体，Na2S2O5作为二氧化硫的廉价来源。通过这种级联方法，可以方便地合成多种γ-酮砜取代的氧吲哚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.