Approach Toward Stereoselective α-Arylation by Pd/Cu-Catalyzed Arylboration of Electron Deficient Alkenes

Abstract

A strategy for the α-arylation of carbonyl compounds is presented. The Cu- and Pd-catalyzed reaction involves 1,2-arylboration of electron deficient alkenes and proceeds with high levels of selectivity. The mechanism is addressed and suggests that a boron ligated enolate is responsible for high selectivity.