Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels?

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Diseases (Basel, Switzerland) Pub Date : 2025-03-06 DOI:10.3390/diseases13030076

Ezek Mathew, Nathan Jones, McKinley Dews, Dominique Neal, Anders Cohen

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Abstract

Background: Recent studies have demonstrated that branched-chain amino acids are neuroprotective and neurorestorative. Branched-chain amino acid supplements are now being recommended to be taken before contact sports to reduce concussions. While peaks and troughs in branched-chain amino acids have previously been reported in hospital settings, the metabolism of a single recommended dose of over-the-counter branched-chain amino acids has yet to be elucidated.

Methods: We analyzed a patented branched-chain amino acid product to assess its metabolism in 10 healthy adults.

Results: Over the defined time points, measured levels of branched-chain amino acids remained significantly elevated when compared to the physiological baseline. The elevations in measured plasma levels indicate that a single oral dose is a viable intake option for increasing levels of branched-chain amino acids.

Conclusions: This information can be leveraged to better plan branched-chain amino acid-based treatment doses in order to treat pathologies such as brain injury.

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为支链氨基酸在神经病理学中的应用奠定基础：单次口服剂量是否能提供数小时的全身水平升高？

背景：最近的研究表明支链氨基酸具有神经保护和神经修复作用。支链氨基酸补充剂现在被推荐在接触性运动之前服用，以减少脑震荡。虽然以前在医院环境中报道过支链氨基酸的高峰和低谷，但非处方支链氨基酸单一推荐剂量的代谢尚未得到阐明。方法：我们分析了一种专利的支链氨基酸产品，以评估其在10名健康成人中的代谢。结果：在规定的时间点上，与生理基线相比，支链氨基酸的测量水平仍显着升高。血浆水平的升高表明单次口服剂量是增加支链氨基酸水平的可行摄入选择。结论：该信息可用于更好地规划支链氨基酸治疗剂量，以治疗脑损伤等病理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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