Evaluating a digital mental health intervention for people with Parkinson's (PACT): acceptability and feasibility randomised controlled trial.

IF 2.8 3区医学 Q3 GERIATRICS & GERONTOLOGY

Aging & Mental Health Pub Date : 2025-03-26 DOI:10.1080/13607863.2025.2478508

Cathryn Pinto, Sam Norton, Patricia Cubi-Molla, Catherine Hurt, Sulayman Chowdhury, Niamh Dooley, Aamina Safwi, Jennie Brown, Riccardo Volpato, Simone Stumpf, Lance McCracken, Angeliki Bogosian

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引用次数: 0

Abstract

Objectives: We developed a web application (PACT app) based on Acceptance and Commitment Therapy to support mental health for people with Parkinson's. Here, we assess the app's acceptability and the feasibility of conducting a randomised controlled trial to evaluate its effectiveness.

Method: This was a two-armed parallel group design with 2:1 allocation to the PACT app or waiting-list control and a single, post-intervention follow-up. Feasibility outcomes included recruitment and retention rate, intervention engagement and satisfaction. Secondary outcomes included measures of anxiety, depression, quality of life, and cost-effectiveness. Treatment effects for secondary outcomes were estimated using linear regression, following the intention-to-treat principle.

Results: Fifty-seven people with Parkinson's were randomised to 4 weeks of PACT app (n = 38) or waiting-list control (n = 19). Recruitment, retention rate, intervention use, and acceptability met our progression criteria. Intervention effects were in the expected direction for all outcomes and largest for measures of depression (Hedges g = -0.96; 95% CI = -1.47 to -0.46) and committed action (Hedges g = 0.87; 95% CI = 0.38 to 1.35).

Conclusion: Progression criteria were met, and PACT was acceptable to people with Parkinson's. It has potential efficacy and cost-effectiveness. A future larger trial to fully evaluate efficacy is needed.Trial registration: ISRCTN65177345 (01/09/2023).

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评估帕金森病患者（PACT）的数字心理健康干预：可接受性和可行性随机对照试验

目的：我们开发了一个基于接受和承诺疗法的网络应用程序（PACT app），以支持帕金森病患者的心理健康。在这里，我们评估应用程序的可接受性和可行性进行随机对照试验，以评估其有效性。方法：这是一个双臂平行组设计，以2:1分配到PACT应用程序或等候名单对照组，并进行单一的干预后随访。可行性结果包括招募率、留任率、干预参与度和满意度。次要结果包括焦虑、抑郁、生活质量和成本效益的测量。根据意向-治疗原则，使用线性回归估计次要结局的治疗效果。结果：57名帕金森患者被随机分为4周PACT应用组（n = 38）和等候组（n = 19）。招募、保留率、干预措施的使用和可接受性符合我们的进展标准。所有结果的干预效果都符合预期方向，其中抑郁症的干预效果最大(对冲系数g = -0.96；95% CI = -1.47至-0.46)和承诺的行动(对冲系数g = 0.87；95% CI = 0.38 ~ 1.35)。结论：满足进展标准，PACT对帕金森病患者是可接受的。它具有潜在的功效和成本效益。未来需要更大规模的试验来全面评估疗效。试验注册：ISRCTN65177345（01/09/2023）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging & Mental Health 医学-精神病学

CiteScore

7.00

自引率

2.90%

发文量

176

审稿时长

4-8 weeks

期刊介绍： Aging & Mental Health provides a leading international forum for the rapidly expanding field which investigates the relationship between the aging process and mental health. The journal addresses the mental changes associated with normal and abnormal or pathological aging, as well as the psychological and psychiatric problems of the aging population. The journal also has a strong commitment to interdisciplinary and innovative approaches that explore new topics and methods. Aging & Mental Health covers the biological, psychological and social aspects of aging as they relate to mental health. In particular it encourages an integrated approach for examining various biopsychosocial processes and etiological factors associated with psychological changes in the elderly. It also emphasizes the various strategies, therapies and services which may be directed at improving the mental health of the elderly and their families. In this way the journal promotes a strong alliance among the theoretical, experimental and applied sciences across a range of issues affecting mental health and aging. The emphasis of the journal is on rigorous quantitative, and qualitative, research and, high quality innovative studies on emerging topics.