Neutrophils in BCR::ABL1 negative MPN: Contributors or bystanders of fibrosis?

IF 5.7 2区医学 Q1 HEMATOLOGY

Blood Reviews Pub Date : 2025-03-20 DOI:10.1016/j.blre.2025.101285

Gaël Vermeersch , Mieke Gouwy , Paul Proost , Sofie Struyf , Timothy Devos

{"title":"Neutrophils in BCR::ABL1 negative MPN: Contributors or bystanders of fibrosis?","authors":"Gaël Vermeersch , Mieke Gouwy , Paul Proost , Sofie Struyf , Timothy Devos","doi":"10.1016/j.blre.2025.101285","DOIUrl":null,"url":null,"abstract":"<div><div><em>BCR::ABL1</em> negative myeloproliferative neoplasms (MPNs) are a heterogenous group of disorders characterized by clonal proliferation of hematopoietic stem and progenitor cells (HSPCs) within the bone marrow. Although the identification of somatic key driver mutations significantly increased both understanding and diagnostic accuracy of MPNs, many questions about the exact pathophysiology remain unanswered. Increased neutrophil count at diagnosis is a well-recognized predictor of worse disease evolution and survival, nonetheless the exact role of neutrophilic granulocytes within MPN pathophysiology is almost unexplored. As the majority of these cells are residing within the bone marrow, they represent a non-negligible entity within the bone marrow niche and its homeostasis. This review describes how neutrophils might contribute to the development of the inflammatory bone marrow niche, and hereby also fibrosis, associated with MPNs. The versatile functions and effects in different contexts emphasize the necessity for future research oriented to bone marrow in addition to peripheral blood.</div></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":"72 ","pages":"Article 101285"},"PeriodicalIF":5.7000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Blood Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0268960X2500030X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

BCR::ABL1 negative myeloproliferative neoplasms (MPNs) are a heterogenous group of disorders characterized by clonal proliferation of hematopoietic stem and progenitor cells (HSPCs) within the bone marrow. Although the identification of somatic key driver mutations significantly increased both understanding and diagnostic accuracy of MPNs, many questions about the exact pathophysiology remain unanswered. Increased neutrophil count at diagnosis is a well-recognized predictor of worse disease evolution and survival, nonetheless the exact role of neutrophilic granulocytes within MPN pathophysiology is almost unexplored. As the majority of these cells are residing within the bone marrow, they represent a non-negligible entity within the bone marrow niche and its homeostasis. This review describes how neutrophils might contribute to the development of the inflammatory bone marrow niche, and hereby also fibrosis, associated with MPNs. The versatile functions and effects in different contexts emphasize the necessity for future research oriented to bone marrow in addition to peripheral blood.

查看原文本刊更多论文

BCR中性粒细胞：ABL1阴性MPN：纤维化的贡献者还是旁观者？

BCR: ABL1阴性骨髓增生性肿瘤（mpn）是一种异质性疾病，其特征是骨髓内造血干细胞和祖细胞（HSPCs）的克隆性增殖。尽管体细胞关键驱动突变的识别显著提高了对mpn的理解和诊断准确性，但关于确切病理生理的许多问题仍未得到解答。诊断时中性粒细胞计数增加是疾病恶化和生存的一个公认的预测因素，尽管如此，中性粒细胞在MPN病理生理中的确切作用几乎未被探索。由于这些细胞大多数存在于骨髓中，它们代表了骨髓生态位及其稳态中不可忽视的实体。这篇综述描述了中性粒细胞如何促进炎症性骨髓生态位的发展，从而促进与mpn相关的纤维化。在不同情况下的多种功能和作用强调了除外周血外进一步研究骨髓的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Blood Reviews 医学-血液学

CiteScore

13.80

自引率

1.40%

发文量

期刊介绍： Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.