Cocamidopropyl betaine: another possible oral healthcare chemical associated with plasma cell lesions of the oral cavity.

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-08 DOI:10.1016/j.oooo.2025.02.019

Jay Saepoo, Nidhi Handoo, Sherry Timmons, Emily Lanzel, Kittiphoj Tikkhanarak, John William Hellstein

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引用次数: 0

Abstract

Objective: To examine the apparent increase in plasma cell lesions of the oral cavity over the course of the past two decades and to propose a possible explanation and therapeutic approach for a subset of these cases.

Study design: Data from cases evaluated at the University of Iowa Surgical Oral Pathology Laboratory (UI-SOP) between July 2003 and May 2024 were retrospectively reviewed to analyze demographics, clinical presentations, and trends in the incidence of these lesions. Additionally, a subset of clinical cases seen at the Oral Pathology Clinic from 2023 to 2024 was examined to explore a potential association with the use of cocamidopropyl betaine (CAPB)-containing toothpaste.

Results: A total of 61 cases were retrieved from UI-SOP archive and analyzed. An increase in the histopathologic diagnoses of oral plasma cell lesions was observed. The clinical case series would seem to indicate CAPB as a possible additional chemical associated with plasma cell gingivitis.

Conclusions: Eliminating the CAPB-containing toothpaste appeared to be a predictable reason for resolution of the gingival/mucosal phenotype in multiple patients. Further collection of cases in a controlled prospective manner may be helpful in confirming the association.

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.