{"title":"Detection of Exosomal microRNA from Malignant Lung Cells Using a Surface Plasmon Resonance Imaging Biosensor.","authors":"Razvan Bocu","doi":"10.3390/bios15030159","DOIUrl":null,"url":null,"abstract":"<p><p>The consideration of micro ribonucleic acid (microRNA) molecules is justified by their ability to act as possible biomarkers, which may be used to detect the most prevalent type of lung cancer: non-small-cell lung cancer (NSCLC). This article describes a surface plasmon resonance imaging (SPRi) biosensor, which was considered to detect malignant lung cells using an Au/Ag heterostructure, as well as the DNA tetrahedron framework (DNATF). Considering the Au/Ag heterostructure and the DNATF, the proposed SPRi biosensor was evaluated. Thus, its detection range belongs to the interval 1.82 fM up to 28 nM. The measured limit of detection of this biosensor is 1.55 fM, and the generated images offer sufficient fidelity to conduct a precise medical analysis. Therefore, patients who suffer from NSCLC may be accurately and efficiently determined. The experimental evaluation, which is presented, suggests that this is a biosensor that is capable of optimizing the clinical detection of NSCLC.</p>","PeriodicalId":48608,"journal":{"name":"Biosensors-Basel","volume":"15 3","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940378/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosensors-Basel","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3390/bios15030159","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The consideration of micro ribonucleic acid (microRNA) molecules is justified by their ability to act as possible biomarkers, which may be used to detect the most prevalent type of lung cancer: non-small-cell lung cancer (NSCLC). This article describes a surface plasmon resonance imaging (SPRi) biosensor, which was considered to detect malignant lung cells using an Au/Ag heterostructure, as well as the DNA tetrahedron framework (DNATF). Considering the Au/Ag heterostructure and the DNATF, the proposed SPRi biosensor was evaluated. Thus, its detection range belongs to the interval 1.82 fM up to 28 nM. The measured limit of detection of this biosensor is 1.55 fM, and the generated images offer sufficient fidelity to conduct a precise medical analysis. Therefore, patients who suffer from NSCLC may be accurately and efficiently determined. The experimental evaluation, which is presented, suggests that this is a biosensor that is capable of optimizing the clinical detection of NSCLC.
Biosensors-BaselBiochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
6.60
自引率
14.80%
发文量
983
审稿时长
11 weeks
期刊介绍：
Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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