Extracellular Vesicles and Pregnancy-Related Hypertensive Disorders: A Descriptive Review on the Possible Implications "From Bench to Bedside".

IF 3.6 3区 生物学 Q1 BIOLOGY
Elena Grossini, Daniela Surico, Sakthipriyan Venkatesan, Mohammad Mostafa Ola Pour, Carmen Imma Aquino, Valentino Remorgida
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引用次数: 0

Abstract

Pregnancy involves extracellular vesicles (EVs) through mechanisms that are poorly understood to date. Furthermore, it is not surprising that EVs may also be involved in the pathophysiology of pre-eclampsia (PE) and gestational hypertension, two clinical conditions with high morbidity and mortality, given their capacity to mediate intracellular communications and regulate inflammation and angiogenesis. We searched major online scientific search engines (PubMed, Google Scholar, Scopus, WES, Embase, etc.) using the terms "Preeclampsia", "Pregnancy", "Hypertension", "Pregnancy-related hypertension", "Extracellular vesicles", "Biomarkers", "Gestation" AND "Obstetrics". Finding potential early biomarkers of risk or illness progression would be essential for the optimum care of expectant mothers with the aforementioned conditions. Nevertheless, none of the various screening assays that have been discovered recently have shown high predictive values. The analysis of EVs in the peripheral blood starting from the first trimester of pregnancy may hold great promise for the possible correlation with gestational hypertension problems and represent a marker of the early stages of the disease. EVs use may be a novel therapeutic approach for the management of various illnesses, as well. In order to define EVs' function in the physiopathology of pregnancy-associated hypertension and PE, as well as their potential as early biomarkers and therapeutic tools, we have compiled the most recent data in this review.

细胞外囊泡与妊娠相关高血压疾病:“从实验室到床边”可能影响的描述性综述。
妊娠涉及细胞外囊泡(EVs),其机制迄今尚不清楚。此外,考虑到EVs介导细胞内通讯、调节炎症和血管生成的能力,EVs也可能参与子痫前期(PE)和妊娠期高血压这两种高发病率和死亡率的临床疾病的病理生理也就不足为奇了。我们检索了主要的在线科学搜索引擎(PubMed、谷歌Scholar、Scopus、WES、Embase等),检索词为“先兆子痫”、“妊娠”、“高血压”、“妊娠相关高血压”、“细胞外囊泡”、“生物标志物”、“妊娠”和“产科”。寻找潜在的风险或疾病进展的早期生物标志物对于具有上述条件的孕妇的最佳护理至关重要。然而,最近发现的各种筛选分析都没有显示出很高的预测价值。从妊娠早期开始的外周血EVs分析可能对与妊娠期高血压问题的可能相关性有很大的希望,并且代表了疾病早期阶段的标志。电动汽车的使用也可能是一种治疗各种疾病的新方法。为了明确ev在妊娠相关高血压和PE的生理病理中的功能,以及它们作为早期生物标志物和治疗工具的潜力,我们在这篇综述中收集了最新的数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biology-Basel
Biology-Basel Biological Science-Biological Science
CiteScore
5.70
自引率
4.80%
发文量
1618
审稿时长
11 weeks
期刊介绍: Biology (ISSN 2079-7737) is an international, peer-reviewed, quick-refereeing open access journal of Biological Science published by MDPI online. It publishes reviews, research papers and communications in all areas of biology and at the interface of related disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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