Decoding the Tumor-Associated Microbiota: From Origins to Nanomedicine Applications in Cancer Therapy.

IF 3.6 3区 生物学 Q1 BIOLOGY
Ruiqi Wang, Weizheng Li, Hongqian Cao, Lei Zhang
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引用次数: 0

Abstract

Growing evidence reveals that the tumor microbiome-comprising distinct microbial communities within neoplastic tissues-exerts a profound influence on cancer initiation, progression, and therapeutic response. These microbes actively reshape the tumor microenvironment (TME) through metabolite secretion, the modulation of immune pathways, and direct interactions with host cells, thereby affecting tumor biology and therapeutic outcomes. Despite substantial heterogeneity among cancer types, recent insights underscore the tumor microbiome's potential as both a diagnostic/prognostic biomarker and a targetable component for innovative treatments. In this review, we synthesize emerging knowledge on the mechanistic roles of tumor-associated microbiota in shaping the TME, with a focus on how these discoveries can guide novel therapeutic strategies. We further explore interdisciplinary advances, including the convergence of microbiomics and nanotechnology, to enhance drug delivery, circumvent resistance, and foster TME remodeling. By highlighting these cutting-edge developments, our review underscores the transformative potential of integrating tumor microbiome research into precision oncology and advancing more personalized cancer therapies.

解码肿瘤相关微生物群:从起源到纳米医学在癌症治疗中的应用。
越来越多的证据表明,肿瘤微生物群——包括肿瘤组织中不同的微生物群落——对癌症的发生、进展和治疗反应有着深远的影响。这些微生物通过代谢产物的分泌、免疫途径的调节以及与宿主细胞的直接相互作用,积极地重塑肿瘤微环境(TME),从而影响肿瘤生物学和治疗结果。尽管癌症类型之间存在很大的异质性,但最近的见解强调了肿瘤微生物组作为诊断/预后生物标志物和创新治疗的可靶向成分的潜力。在这篇综述中,我们综合了关于肿瘤相关微生物群在形成TME中的机制作用的新知识,重点是这些发现如何指导新的治疗策略。我们进一步探索跨学科的进展,包括微生物组学和纳米技术的融合,以增强药物传递,规避耐药性,并促进TME重塑。通过强调这些前沿发展,我们的综述强调了将肿瘤微生物组研究整合到精确肿瘤学和推进更个性化的癌症治疗中的变革潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biology-Basel
Biology-Basel Biological Science-Biological Science
CiteScore
5.70
自引率
4.80%
发文量
1618
审稿时长
11 weeks
期刊介绍: Biology (ISSN 2079-7737) is an international, peer-reviewed, quick-refereeing open access journal of Biological Science published by MDPI online. It publishes reviews, research papers and communications in all areas of biology and at the interface of related disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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