Epidemiology with real-world data: deep endometriosis in women of reproductive age.

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL
Einstein-Sao Paulo Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI:10.31744/einstein_journal/2025AO1259
Nilson Abrão Szylit, Luciana Cristina Pasquini Raiza, Anucha Andrade Schindler Leal, Sérgio Podgaec
{"title":"Epidemiology with real-world data: deep endometriosis in women of reproductive age.","authors":"Nilson Abrão Szylit, Luciana Cristina Pasquini Raiza, Anucha Andrade Schindler Leal, Sérgio Podgaec","doi":"10.31744/einstein_journal/2025AO1259","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Szylit et al. conducted a descriptive prevalence study combined with a cross-sectional observational study in a public primary care clinic. Using real-world data, they determined the prevalence of endometriosis in women selected without prior screening for the condition, employing pelvic and transvaginal ultrasound. This study represents the first of its kind in Latin America. This study represents the first investigation into the prevalence of deep endometriosis within outpatient services. Utilizing real-world data, this study explores the prevalence of endometriosis. The prevalence of endometriosis among women of reproductive age is 6.4% (based on real-world data). The prevalence of endometriosis in women experiencing pelvic pain is 34.2%. Infertility is 6.5 times more common in women diagnosed with endometriosis. The presence of palpable posterior cul-de-sac nodules or a retroverted uterus suggests endometriosis.</p><p><strong>Objective: </strong>Endometriosis is characterized by the presence of glandular tissue or endometrial stroma outside the uterus. This study aimed to determine the prevalence of symptomatic deep endometriosis and the clinical factors associated with this condition in women of reproductive age.</p><p><strong>Methods: </strong>A descriptive prevalence study combined with a cross-sectional observational study was conducted between 2017 and 2021 at a public primary care outpatient clinic in Brazil. Women of reproductive age with at least one of the following symptoms were included in the study: deep dyspareunia, dysmenorrhea, chronic pelvic pain, intestinal or urinary symptoms during the menstrual cycle, or infertility. A sample size calculation indicated that an estimated sample of 269 patients was required for the study. Qualitative variables are described as absolute and relative frequencies, while quantitative variables are expressed as medians and quartiles. Factors associated with endometriosis were analyzed using logistic regression and multiple models.</p><p><strong>Results: </strong>Data from 1,445 patients were considered. Among these, 92 were diagnosed with deep endometriosis, resulting in a prevalence of 6.4% (95%CI= 5.2-7.7) and 34.2% among women with pelvic pain (95%CI= 28.8-40.1). Women with palpable posterior cul-de-sac nodules (0R= 3.58, 95%CI= 1.68-7.63, p = 0.001) or a retroverted uterus (0R= 2.36, 95%CI= 1.28-4.37, p = 0.006) were more likely to have endometriosis.</p><p><strong>Conclusion: </strong>Using real-world data, the prevalence of deep endometriosis was found to be 6.4% in women of reproductive age and 34.2% in those with pelvic pain. The primary clinical variables associated with endometriosis are palpable posterior cul-de-sac nodules and a retroverted uterus.</p>","PeriodicalId":47359,"journal":{"name":"Einstein-Sao Paulo","volume":"23 ","pages":"eAO1259"},"PeriodicalIF":1.1000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Einstein-Sao Paulo","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31744/einstein_journal/2025AO1259","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Szylit et al. conducted a descriptive prevalence study combined with a cross-sectional observational study in a public primary care clinic. Using real-world data, they determined the prevalence of endometriosis in women selected without prior screening for the condition, employing pelvic and transvaginal ultrasound. This study represents the first of its kind in Latin America. This study represents the first investigation into the prevalence of deep endometriosis within outpatient services. Utilizing real-world data, this study explores the prevalence of endometriosis. The prevalence of endometriosis among women of reproductive age is 6.4% (based on real-world data). The prevalence of endometriosis in women experiencing pelvic pain is 34.2%. Infertility is 6.5 times more common in women diagnosed with endometriosis. The presence of palpable posterior cul-de-sac nodules or a retroverted uterus suggests endometriosis.

Objective: Endometriosis is characterized by the presence of glandular tissue or endometrial stroma outside the uterus. This study aimed to determine the prevalence of symptomatic deep endometriosis and the clinical factors associated with this condition in women of reproductive age.

Methods: A descriptive prevalence study combined with a cross-sectional observational study was conducted between 2017 and 2021 at a public primary care outpatient clinic in Brazil. Women of reproductive age with at least one of the following symptoms were included in the study: deep dyspareunia, dysmenorrhea, chronic pelvic pain, intestinal or urinary symptoms during the menstrual cycle, or infertility. A sample size calculation indicated that an estimated sample of 269 patients was required for the study. Qualitative variables are described as absolute and relative frequencies, while quantitative variables are expressed as medians and quartiles. Factors associated with endometriosis were analyzed using logistic regression and multiple models.

Results: Data from 1,445 patients were considered. Among these, 92 were diagnosed with deep endometriosis, resulting in a prevalence of 6.4% (95%CI= 5.2-7.7) and 34.2% among women with pelvic pain (95%CI= 28.8-40.1). Women with palpable posterior cul-de-sac nodules (0R= 3.58, 95%CI= 1.68-7.63, p = 0.001) or a retroverted uterus (0R= 2.36, 95%CI= 1.28-4.37, p = 0.006) were more likely to have endometriosis.

Conclusion: Using real-world data, the prevalence of deep endometriosis was found to be 6.4% in women of reproductive age and 34.2% in those with pelvic pain. The primary clinical variables associated with endometriosis are palpable posterior cul-de-sac nodules and a retroverted uterus.

研究背景Szylit 等人在一家公共初级保健诊所开展了一项描述性患病率研究和一项横断面观察研究。他们利用真实世界的数据,通过盆腔和经阴道超声波检查,确定了未进行子宫内膜异位症筛查的妇女中子宫内膜异位症的患病率。这项研究在拉丁美洲尚属首次。这项研究是对门诊服务中深部子宫内膜异位症患病率的首次调查。本研究利用真实世界的数据,探讨了子宫内膜异位症的患病率。育龄妇女的子宫内膜异位症患病率为 6.4%(基于真实世界的数据)。盆腔疼痛妇女的子宫内膜异位症患病率为 34.2%。在确诊患有子宫内膜异位症的女性中,不孕症的发病率是其他女性的 6.5 倍。可触及的后阴道结节或子宫后倾提示子宫内膜异位症:子宫内膜异位症的特征是子宫外存在腺体组织或子宫内膜基质。本研究旨在确定育龄妇女中无症状深部子宫内膜异位症的患病率以及与该病症相关的临床因素:2017年至2021年期间,在巴西的一家公立初级保健门诊部开展了一项描述性患病率研究和横断面观察研究。研究对象包括至少有以下一种症状的育龄妇女:深度痛经、痛经、慢性盆腔疼痛、月经周期中的肠道或泌尿系统症状或不孕症。样本量计算显示,该研究估计需要 269 个患者样本。定性变量以绝对频率和相对频率表示,定量变量以中位数和四分位数表示。使用逻辑回归和多重模型分析了与子宫内膜异位症相关的因素:研究考虑了 1 445 名患者的数据。其中,92 人被确诊为深部子宫内膜异位症,患病率为 6.4%(95%CI= 5.2-7.7),在有盆腔疼痛的妇女中,患病率为 34.2%(95%CI= 28.8-40.1)。可触及后涵道结节(0R= 3.58,95%CI= 1.68-7.63,p = 0.001)或子宫后倾(0R= 2.36,95%CI= 1.28-4.37,p = 0.006)的女性更有可能患有子宫内膜异位症:结论:利用真实世界的数据发现,育龄妇女的深部子宫内膜异位症发病率为 6.4%,盆腔疼痛妇女的发病率为 34.2%。与子宫内膜异位症相关的主要临床变量是可触及的后阴道结节和子宫后倾。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Einstein-Sao Paulo
Einstein-Sao Paulo MEDICINE, GENERAL & INTERNAL-
CiteScore
2.00
自引率
0.00%
发文量
210
审稿时长
38 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信