{"title":"Enhanced Protein Separation Performance of Cellulose Acetate Membranes Modified with Covalent Organic Frameworks.","authors":"Shurui Shao, Maoyu Liu, Baifu Tao, Kayode Hassan Lasisi, Wenqiao Meng, Xing Wu, Kaisong Zhang","doi":"10.3390/membranes15030084","DOIUrl":null,"url":null,"abstract":"<p><p>As a porous crystalline material, covalent organic frameworks (COFs) have attracted significant attention due to their extraordinary features, such as an ordered pore structure and excellent stability. Synthesized through the aldehyde amine condensation reaction, TpPa-1 COFs (Triformylphloroglucinol-p-Phenylenediamine-1 COFs) were blended with cellulose acetate (CA) to form a casting solution. The TpPa-1 COF/CA ultrafiltration membrane was then prepared using the non-solvent-induced phase inversion (NIPS) method. The influence of TpPa-1 COFs content on the hydrophilicity, stability and filtration performance of the modified membrane was studied. Due to the hydrophilic groups in TpPa-1 COFs and the network structure formed by covalent bonds, the modified CA membranes exhibited higher hydrophilicity and lower protein adsorption compared with the pristine CA membrane. The porous crystalline structure of TpPa-1 COFs increased the water permeation path in the CA membrane, improving the permeability of the modified membrane while maintaining an outstanding bovine serum albumin (BSA) rejection. Furthermore, the addition of TpPa-1 COFs reduced protein adsorption on the CA membrane and overcame the trade-off between permeability and selectivity in CA membrane bioseparation applications. This approach provides a sustainable method for enhancing membrane performance while enhancing the application of membranes in protein purification.</p>","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"15 3","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944191/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Membranes","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3390/membranes15030084","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
As a porous crystalline material, covalent organic frameworks (COFs) have attracted significant attention due to their extraordinary features, such as an ordered pore structure and excellent stability. Synthesized through the aldehyde amine condensation reaction, TpPa-1 COFs (Triformylphloroglucinol-p-Phenylenediamine-1 COFs) were blended with cellulose acetate (CA) to form a casting solution. The TpPa-1 COF/CA ultrafiltration membrane was then prepared using the non-solvent-induced phase inversion (NIPS) method. The influence of TpPa-1 COFs content on the hydrophilicity, stability and filtration performance of the modified membrane was studied. Due to the hydrophilic groups in TpPa-1 COFs and the network structure formed by covalent bonds, the modified CA membranes exhibited higher hydrophilicity and lower protein adsorption compared with the pristine CA membrane. The porous crystalline structure of TpPa-1 COFs increased the water permeation path in the CA membrane, improving the permeability of the modified membrane while maintaining an outstanding bovine serum albumin (BSA) rejection. Furthermore, the addition of TpPa-1 COFs reduced protein adsorption on the CA membrane and overcame the trade-off between permeability and selectivity in CA membrane bioseparation applications. This approach provides a sustainable method for enhancing membrane performance while enhancing the application of membranes in protein purification.
MembranesChemical Engineering-Filtration and Separation
CiteScore
6.10
自引率
16.70%
发文量
1071
审稿时长
11 weeks
期刊介绍:
Membranes (ISSN 2077-0375) is an international, peer-reviewed open access journal of separation science and technology. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.