Enhanced Protein Separation Performance of Cellulose Acetate Membranes Modified with Covalent Organic Frameworks.

IF 3.3 4区 工程技术 Q2 CHEMISTRY, PHYSICAL
Shurui Shao, Maoyu Liu, Baifu Tao, Kayode Hassan Lasisi, Wenqiao Meng, Xing Wu, Kaisong Zhang
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引用次数: 0

Abstract

As a porous crystalline material, covalent organic frameworks (COFs) have attracted significant attention due to their extraordinary features, such as an ordered pore structure and excellent stability. Synthesized through the aldehyde amine condensation reaction, TpPa-1 COFs (Triformylphloroglucinol-p-Phenylenediamine-1 COFs) were blended with cellulose acetate (CA) to form a casting solution. The TpPa-1 COF/CA ultrafiltration membrane was then prepared using the non-solvent-induced phase inversion (NIPS) method. The influence of TpPa-1 COFs content on the hydrophilicity, stability and filtration performance of the modified membrane was studied. Due to the hydrophilic groups in TpPa-1 COFs and the network structure formed by covalent bonds, the modified CA membranes exhibited higher hydrophilicity and lower protein adsorption compared with the pristine CA membrane. The porous crystalline structure of TpPa-1 COFs increased the water permeation path in the CA membrane, improving the permeability of the modified membrane while maintaining an outstanding bovine serum albumin (BSA) rejection. Furthermore, the addition of TpPa-1 COFs reduced protein adsorption on the CA membrane and overcame the trade-off between permeability and selectivity in CA membrane bioseparation applications. This approach provides a sustainable method for enhancing membrane performance while enhancing the application of membranes in protein purification.

共价有机框架修饰醋酸纤维素膜的蛋白质分离性能
共价有机骨架(COFs)作为一种多孔晶体材料,因其有序的孔隙结构和优异的稳定性等特点而受到广泛关注。通过醛胺缩合反应合成TpPa-1 COFs (triformylphloroglucinol -对苯二胺-1 COFs),与醋酸纤维素(CA)混合形成铸造溶液。采用非溶剂诱导相转化(NIPS)法制备了TpPa-1 COF/CA超滤膜。研究了tpa -1 COFs含量对改性膜亲水性、稳定性和过滤性能的影响。由于TpPa-1 COFs中的亲水性基团和共价键形成的网络结构,改性后的CA膜与原始CA膜相比具有更高的亲水性和更低的蛋白质吸附。TpPa-1 COFs的多孔晶体结构增加了CA膜中的水渗透路径,提高了改性膜的渗透性,同时保持了出色的牛血清白蛋白(BSA)排斥。此外,TpPa-1 COFs的加入减少了CA膜上蛋白质的吸附,克服了CA膜生物分离应用中渗透性和选择性之间的权衡。这种方法为提高膜的性能提供了一种可持续的方法,同时也促进了膜在蛋白质纯化中的应用。
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来源期刊
Membranes
Membranes Chemical Engineering-Filtration and Separation
CiteScore
6.10
自引率
16.70%
发文量
1071
审稿时长
11 weeks
期刊介绍: Membranes (ISSN 2077-0375) is an international, peer-reviewed open access journal of separation science and technology. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.
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